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      Combined effect of PLGA and curcumin on wound healing activity.

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          Abstract

          Wound healing is a complex process involving many interdependent and overlapping sequences of physiological actions. The application of exogenous lactate released from poly (lactic-co-glycolic acid) (PLGA) polymer accelerated angiogenesis and wound healing processes. Curcumin is a well-known topical wound healing agent for both normal and diabetic-impaired wounds. Hence, we hypothesized that the PLGA nanoparticles encapsulating curcumin could much potentially accelerate the wound healing. In a full thickness excisional wound healing mouse model, PLGA-curcumin nanoparticles showed a twofold higher wound healing activity compared to that of PLGA or curcumin. Histology and RT-PCR studies confirmed that PLGA-curcumin nanoparticles exhibited higher re-epithelialization, granulation tissue formation and anti-inflammatory potential. PLGA nanoparticles offered various benefits for the encapsulated curcumin like protection from light degradation, enhanced water solubility and showed a sustained release of curcumin over a period of 8 days. In conclusion, we demonstrated the additive effect of lactic acid from PLGA and encapsulated curcumin for the active healing of wounds.

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          Author and article information

          Journal
          J Control Release
          Journal of controlled release : official journal of the Controlled Release Society
          1873-4995
          0168-3659
          Oct 28 2013
          : 171
          : 2
          Affiliations
          [1 ] Pharmaceutics and Drug Delivery, Louvain Drug Research Institute, Université catholique de Louvain, 1200 Brussels, Belgium.
          Article
          S0168-3659(13)00409-4
          10.1016/j.jconrel.2013.07.015
          23891622
          726a69a8-682c-4e49-8f2b-c8d8e0fe805a
          © 2013.
          History

          Curcumin,Drug delivery,Nanoparticles,Poly (lactic-co-glycolic acid),Skin wound healing

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