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      Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities

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          Abstract

          The flower buds of Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids ( 1–12), including two new ursane-type nortriterpenes, , 24-dihydroxy-23-nor-ursolic acid ( 1) and , 4 α-dihydroxy-23-nor-ursolic acid ( 2). Their structures were established by multiple spectroscopic methods and comparison with literature data. All isolated compounds were evaluated for their anti-inflammatory effects in LPS-activated RAW264.7 cells. Compounds 1 and 2 exhibited inhibitory effects on iNOS at the concentration of 30 μmol·L -1.

          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 January 2019
          : 17
          : 1
          : 27-32
          Affiliations
          [1] 1 Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China
          [2] 2 College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
          [3] 3 Faculty of Chinese Medicine, Macau University of Science and Technology and State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology), Macau 999078, China
          [4] 4 XiangXue Academician workstation, Xiangxue Pharmaceutical Co., Ltd., Guangzhou 510663, China
          Author notes
          *Corresponding author: YU Yang, E-mails: 1018yuyang@ 123456163.com ; YAO Xin-Sheng, tyaoxs@ 123456jnu.edu.cn

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(19)30006-8
          10.1016/S1875-5364(19)30006-8
          30704620
          726fe49e-1103-4728-8e2e-dc74a446af56
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          History
          : 10 September 2018
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 81602984
          Award ID: 81630097
          Funded by: Science and Technology Planning Project of Guangdong Province
          Award ID: 2015B030301005
          This work was supported by the National Natural Science Foundation of China (Nos. 81602984 and 81630097) and Science and Technology Planning Project of Guangdong Province (No. 2015B030301005)
          Categories
          Special topic

          Medicine,Pharmaceutical chemistry,Pharmacology & Pharmaceutical medicine,Complementary & Alternative medicine
          iNOS,Ursane-type nortriterpenes,Anti-inflammation, Lonicerae Flos , Lonicera macranthoides

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