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      Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities

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          Abstract

          The flower buds of Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids ( 1–12), including two new ursane-type nortriterpenes, , 24-dihydroxy-23-nor-ursolic acid ( 1) and , 4 α-dihydroxy-23-nor-ursolic acid ( 2). Their structures were established by multiple spectroscopic methods and comparison with literature data. All isolated compounds were evaluated for their anti-inflammatory effects in LPS-activated RAW264.7 cells. Compounds 1 and 2 exhibited inhibitory effects on iNOS at the concentration of 30 μmol·L -1.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 January 2019
          : 17
          : 1
          : 27-32
          Affiliations
          1 Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China
          2 College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
          3 Faculty of Chinese Medicine, Macau University of Science and Technology and State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology), Macau 999078, China
          4 XiangXue Academician workstation, Xiangxue Pharmaceutical Co., Ltd., Guangzhou 510663, China
          Author notes
          *Corresponding author: YU Yang, E-mails: 1018yuyang@ 123456163.com ; YAO Xin-Sheng, tyaoxs@ 123456jnu.edu.cn

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(19)30006-8
          10.1016/S1875-5364(19)30006-8
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 81602984
          Award ID: 81630097
          Funded by: Science and Technology Planning Project of Guangdong Province
          Award ID: 2015B030301005
          This work was supported by the National Natural Science Foundation of China (Nos. 81602984 and 81630097) and Science and Technology Planning Project of Guangdong Province (No. 2015B030301005)
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