Dietary Fatty Acid Supplementation Modulates the Urinary Excretion of Calcium and Oxalate in the Rat

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Abstract

Background: An anomalous plasma phospholipid polyunsaturated fatty acid composition has been reported in calcium nephrolithiasis, and was proposed to play a crucial role in the pathogenesis of hypercalciuria and hyperoxaluria, well-known risk factors for lithogenesis. Methods: To confirm this hypothesis, we administered rats three different diets rich in coconut, soybean and fish oils, and evaluated their effect on plasma urinary calcium and oxalate excretion, since the quality of fatty acids represents an important factor able to influence the activity of delta-6-desaturase, the rate-limiting enzyme in the biosynthetic pathway of highly unsaturated fatty acids. Results: In comparison with coconut and fish oil, dietary supplementation with soybean oil increased plasma phospholipid arachidonic acid and serum 1,25-vitamin D<sub>3</sub> values, as well as renal tissue calcium content and urinary excretion of sodium, oxalate and calcium. Conclusions: Our findings demonstrate that the quality of fatty acids may modify the urine excretion of calcium and oxalate, confirming our previous hypothesis of a pathogenetic link between cellular membrane phospholipid polyunsaturated fatty acid composition and calcium nephrolithiasis. In addition, our study provides new insights into the relationship between dietary, environmental factors and renal stone disease.

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Is arachidonic acid a second messenger in signal transduction?

Zvi Naor (1991)

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 2002

Publication date (Print): July 2002

Publication date (Electronic): 01 July 2002

Volume: 91

Issue: 3

Pages: 486-491

Affiliations

^aDepartment of Medical-Surgery Sciences, University of Padua, Italy; ^bDepartment of Pathology, University of Florida, Gainesville, Fla., USA

Article

Publisher ID: 64292 Other ID: Nephron 2002;91:486–491

DOI: 10.1159/000064292

PubMed ID: 12119482

SO-VID: 729331e7-2a4d-4cd8-a890-a8e9012ee274

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