Emergence of Extensively Drug-Resistant Proteus mirabilis Harboring a Conjugative NDM-1 Plasmid and a Novel Salmonella Genomic Island 1 Variant, SGI1-Z.

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Abstract

Acquisition of blaNDM-1 in bacterial species, such as Proteus mirabilis that is intrinsically resistant to tetracycline, tigecycline and colistin, will make clinical treatment extremely difficult. Here, we characterized an NDM-1-producing clinical isolate of P. mirabilis (PM58) that displayed an extensively drug-resistant (XDR) phenotype, susceptible only to aztreonam. Molecular analysis revealed that PM58 harbored both a conjugative NDM-1 plasmid and a novel Salmonella genomic island 1 variant on chromosome.

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Journal

Journal ID (iso-abbrev): Antimicrob. Agents Chemother.

Title: Antimicrobial agents and chemotherapy

ISSN (Electronic): 1098-6596

ISSN (Print): 0066-4804

Publication date (Electronic): Oct 2015

Volume: 59

Issue: 10

Affiliations

[1 ] School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.

[2 ] Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.

[3 ] The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

[4 ] The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China xjfeng62688@163.com liuhm@zzu.edu.cn.

[5 ] School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China xjfeng62688@163.com liuhm@zzu.edu.cn.

Article

Publisher Item ID: AAC.00292-15

DOI: 10.1128/AAC.00292-15

PMC ID: 4576069

PubMed ID: 26195511

SO-VID: 729950a7-fc51-430c-91ff-cfcd3a39fd81

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