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Influence of Splenectomy on Human Acute Tubular Necrosis
Abstract
The incidence of acute tubular necrosis (need for hemodialysis immediately after transplantation) and its severity (the number of days dialysis was needed) were studied in 299 patients who were randomized prior to transplantation into undergoing splenectomy or not having splenectomy. There was no difference in the incidence of acute tubular necrosis between splenectomized and nonsplenectomized patients who received cadaveric grafts or kidneys from living related donors. In those patients in the cadaveric group who had acute tubular necrosis, the duration of need for dialysis was significantly less (p < 0.05) in the splenectomized group (x = 8.9 days) when compared to the nonsplenectomized group (x = 13.2 days). Animal experiments indicate that sustained prostaglandin release may be responsible for the decreased incidence and amelioration of acute tubular necrosis in splenectomized animals. Our study suggests that conclusions made in dogs about the influence of splenectomy on acute tubular necrosis may be applied to humans. Prostaglandin infusion may be a worthwhile method to abolish or ameliorate human acute tubular necrosis.
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183150 Nephron 1984;36:187–190Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.