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      Tumor-associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells

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          Abstract

          Periostin (POSTN) secreted by intrahepatic cholangiocarcinoma stem cells (ICSCs) serves important roles in promoting tumor progression. The present study aimed to investigate POSTN-recruited tumor-associated macrophages (TAMs) in intrahepatic cholangiocarcinoma (ICC). A total of 50 cases were used to investigate the distribution of ICSCs and TAMs in ICC. HCCC-9810 cells were sorted by cluster of differentiation (CD)44, the expression of POSTN of CD44 + (cancer stem cells) and CD44 cells (non-cancer stem cells), and medium were evaluated by western blot analysis. HCCC-9810 cells and THP-1 macrophages were used to detect the effects of POSTN on recruiting TAMs in vitro. The present study revealed that CD44 + cells in ICC tissues and the HCCC-9810 cell line were associated with high POSTN secretion levels. Furthermore, POSTN was associated with TAM density in primary ICC tissues. Additionally, POSTN increased the migration of TAMs derived from THP-1 cells. These findings suggested that POSTN secreted by ICSCs may serve important functions in TAM recruitment, and it may be a potential curative strategy to target the tumor microenvironment in ICC.

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          Author and article information

          Journal
          Oncol Lett
          Oncol Lett
          OL
          Oncology Letters
          D.A. Spandidos
          1792-1074
          1792-1082
          June 2018
          29 March 2018
          29 March 2018
          : 15
          : 6
          : 8681-8686
          Affiliations
          [1 ]Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hunan Normal University-Hunan Provincial People's Hospital, Changsha, Hunan 410006, P.R. China
          [2 ]Department of General Surgery, Yiyang Central Hospital, Yiyang, Hunan 413000, P.R. China
          [3 ]Department of Pharmacy, Yiyang Central Hospital, Yiyang, Hunan 413000, P.R. China
          [4 ]Intistute of Clinical Medical Research, The First Affiliated Hospital of Hunan Normal University-Hunan Provincial People's Hospital, Changsha, Hunan 410006, P.R. China
          Author notes
          Correspondence to: Dr Bo Jiang, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hunan Normal University-Hunan Provincial People's Hospital, 61 Jiefang Road, Changsha, Hunan 410006, P.R. China, E-mail: jiangbo_hph@ 123456163.com
          [*]

          Contributed equally

          Article
          PMC5950521 PMC5950521 5950521 OL-0-0-8372
          10.3892/ol.2018.8372
          5950521
          29805605
          Copyright © 2018, Spandidos Publications
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