There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Since the identification of Toll-like receptors, our knowledge about pattern-recognition
receptors (PRRs) has increased rapidly. Classes of PRRs that have been recently discovered
include RIG-I-like receptors, Nod-like receptors, and C-type lectin receptors. Recent
studies have started to clarify the molecular basis of PRR-ligand interactions, yet
the numbers of PRRs and their ligands continue to increase. New technologies have
elucidated the network regulation of immune responses at the cellular and in vivo
levels. We review the most recent discoveries about PRRs and their ligands, their
roles in intracellular and in vivo regulation of immune responses, and the systems
biology of innate immunity.
Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby,
Inc. All rights reserved.