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Evaluation of clinical and laboratory markers of cardiometabolic risk in overweight and obese children and adolescents

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      Abstract

      OBJECTIVE:This study analyzed the frequency of cardiometabolic risk markers and metabolic syndrome occurrence in overweight and obese children and adolescents.METHODS:The participants included 161 overweight (n=65) and obese (n=96) individuals aged between 5 and 19 years. Clinical markers were assessed (body mass index, body fat percentage, waist circumference, acanthosis, systolic and diastolic blood pressures, laboratory parameters [glucose, insulin, cholesterol (total and fractions) and triglyceride levels and homeostasis model assessment of insulin resistance (HOMA-IR) index] and leptin and adiponectin levels). The frequency of changes, odds ratios and correlations among markers were determined. Metabolic syndrome was assessed according to International Diabetes Federation criteria.RESULTS:A high frequency of acanthosis (51.6%); increased waist circumference (45.4%), systolic blood pressure / diastolic blood pressure (8.1% / 9.3%), glucose (10%), insulin (36.9%) and HOMA-IR (44.3%) values; and reduced high-density lipoprotein levels (47.2%) were observed. Leptin levels were increased in 95% of obese and in 66% of overweight subjects. Adiponectin was decreased in 29.5% of obese and in 34% of overweight subjects. An odd ratio analysis revealed a greater probability of increased waist circumference (9.0), systolic blood pressure (4.1), triglyceride (2.3) and insulin (2.9) levels and HOMA-IR (3.0) in the obese group than in the overweight group. The clinical and laboratory parameters and leptin levels exhibited significant correlations, whereas adiponectin was negatively correlated with systolic blood pressure. The occurrence rate of metabolic syndrome was 13.6%.CONCLUSIONS:The high frequency of changes in clinical, laboratory and adipokine markers indicates the need for early interventions aimed at preventing cardiometabolic complications in adulthood.

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      Most cited references 53

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            Author and article information

            Affiliations
            [I ]Divisão de Endocrinologia, Faculdade de Medicina, Universidade Federal do Triângulo Mineiro, Uberaba/MG, Brazil
            [II ]Divisão de Enfermagem e Educação Comunitária, Faculdade de Medicina, Universidade Federal do Triângulo Mineiro, Uberaba/MG, Brazil
            [III ]Divisão de Imunologia, Faculdade de Medicina, Universidade Federal do Triângulo Mineiro, Uberaba/MG, Brazil
            Author notes
            *Corresponding author. E-mail: helomcp@ 123456terra.com.br
            Journal
            Clinics (Sao Paulo)
            Clinics (Sao Paulo)
            Clinics
            Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
            1807-5932
            1980-5322
            January 2017
            January 2017
            : 72
            : 1
            : 36-43
            5251200
            10.6061/clinics/2017(01)07
            cln_72p36
            Copyright © 2017 CLINICS

            This is an Open Access article distributed under the terms of the Creative Commons License ( http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.

            Categories
            Clinical Science

            Medicine

            obesity, cardiometabolic risk, overweight, adolescents, children

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