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      One Hundred Years of Linkage Disequilibrium

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      * , 1 ,

      Genetics

      Genetics Society of America

      LD, recombination, population size, genetic drift, GWAS, genomic prediction

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          Abstract

          The year 2018 marks 100 years since the concept of linkage disequilibrium (LD) was introduced, and 50 years since the importance of chance segregation in generating LD was recognized. GenomeWide Association Studies (GWAS) now use...

          Abstract

          One hundred years ago, the first population genetic calculations were made for two loci. They indicated that populations should settle down to a state where the frequency of an allele at one locus is independent of the frequency of an allele at a second locus, even if these loci are linked. Fifty years later it was realized what is obvious in retrospect, that these calculations ignored the effect of chance segregation of linked loci, an effect now widely recognized following the association of closely linked markers (SNPs) with rare genetic diseases. Linkage disequilibrium is now accepted as the norm for closely linked loci, leading to powerful applications in the mapping of disease alleles and quantitative trait loci, in the detection of sites of selection in the human genome, in the application of genomic prediction of quantitative traits in animal and plant breeding, in the estimation of population size, and in the dating of population divergence.

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          Author and article information

          Journal
          Genetics
          Genetics
          genetics
          genetics
          genetics
          Genetics
          Genetics Society of America
          0016-6731
          1943-2631
          July 2018
          28 June 2018
          : 209
          : 3
          : 629-636
          Affiliations
          [* ]Evolution and Ecology Research Centre, University of New South Wales, Sydney, 2052, Australia
          []Institute of Evolutionary Biology, University of Edinburgh, EH9 3FL, United Kingdom
          Author notes
          [1 ]Corresponding author: E-mail: j.sved@ 123456unsw.edu.au
          Article
          PMC6028242 PMC6028242 6028242 300642
          10.1534/genetics.118.300642
          6028242
          29967057
          72e46b3d-44cc-4d0b-923a-c856ee39a9fb
          Copyright © 2018 by the Genetics Society of America
          Page count
          Figures: 1, Tables: 0, Equations: 5, References: 66, Pages: 8
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