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      Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin.

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          Abstract

          Psilocybin is a classic psychedelic drug that has a history of use in psychotherapy. One of the rationales for its use was that it aids emotional insight by lowering psychological defences.

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          Belief and recollection of autobiographical memories.

          In three experiments, undergraduates rated autobiographical memories on scales derived from existing theories of memory. In multiple regression analyses, ratings of the degree to which subjects recollected (i.e., relived) their memories were predicted by visual imagery, auditory imagery, and emotions, whereas ratings of belief in the accuracy of their memories were predicted by knowledge of the setting. Recollection was predicted equally well in between- and within-subjects analyses, but belief consistently had smaller correlations and multiple regression predictions between subjects; individual differences in the cognitive scales that we measured could not account well for individual differences in belief. In contrast, measures of mood (Beck Depression Index) and dissociation (Dissociative Experience Scale) added predictive value for belief, but not for recollection. We also found that highly relived memories almost always had strong visual images and that remember/know judgments made on autobiographical memories were more closely related to belief than to recollection.
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            THE BRAIN’S RECORD OF AUDITORY AND VISUAL EXPERIENCE

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              Mental phenomena evoked by electrical stimulation of the human hippocampal formation and amygdala.

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                Author and article information

                Journal
                Br J Psychiatry
                The British journal of psychiatry : the journal of mental science
                1472-1465
                0007-1250
                Mar 2012
                : 200
                : 3
                Affiliations
                [1 ] Imperial College London, Neuropsychopharmacology Unit, 5th Floor, Burlington Danes Building, 160 Du Cane Road, London W12 0NN, UK. r.carhart-harris@imperial.ac.uk
                Article
                bjp.bp.111.103309
                10.1192/bjp.bp.111.103309
                22282432
                7303cd95-1ca7-4755-9375-f6b6533a8776
                History

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