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      Plasma Somatomedin Activity and Urinary Hydroxyproline Excretion during Administration of Human Growth Hormone in Children with Short Stature


      Hormone Research in Paediatrics

      S. Karger AG

      Somatomedin, Hydroxyproline, Growth hormone, Short stature

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          Growth velocity, somatomedin activity (SM-act) and total urinary hydroxyproline excretion (THP) were studied in 9 prepubertal short children on long-term human growth hormone (hGH) therapy, and compared to the short-term responses to hGH, described in the accompanying paper. Positive correlations were found between the short-term increases of either SM-act or THP and growth acceleration, but these were too weak to be used as a predictor. On a schedule of biweekly injections, pre-injection SM-act values were only slightly higher than pre-treatment values, but post-injection values were considerably higher and similar to the values obtained with comparable hGH doses in the short-term study. There was an excellent relationship of the increment of SM-act during chronic therapy over untreated values and the increases of growth velocity. During the first year on hGH therapy the mean SM-act, mean THP and growth acceleration showed strong correlations.

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          Author and article information

          Hormone Research in Paediatrics
          S. Karger AG
          26 November 2008
          : 19
          : 4
          : 216-223
          Department of Paediatrics, University Children’s Hospital, Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands
          179891 Horm Res 1984;19:216–223
          © 1984 S. Karger AG, Basel

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          Page count
          Pages: 8


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