Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets.

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Abstract

Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a highly aggressive neoplasm, whose biologic relationship to small cell lung carcinoma (SCLC) versus non-SCLC (NSCLC) remains unclear, contributing to uncertainty regarding optimal clinical management. To clarify these relationships, we analyzed genomic alterations in LCNEC compared with other major lung carcinoma types.

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Journal

Journal ID (iso-abbrev): Clin. Cancer Res.

Title: Clinical cancer research : an official journal of the American Association for Cancer Research

ISSN: 1078-0432

ISSN (Print): 1078-0432

Publication date (Electronic): Jul 15 2016

Volume: 22

Issue: 14

Affiliations

[1 ] Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. rekhtman@mskcc.org.

[2 ] Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

[3 ] Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.

[4 ] Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York.

[5 ] Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.

[6 ] Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

[7 ] Bioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, New York.

[8 ] Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York.

[9 ] Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Article

Publisher Item ID: 1078-0432.CCR-15-2946 Mid ID: NIHMS808724

DOI: 10.1158/1078-0432.CCR-15-2946

PMC ID: 4995776

PubMed ID: 26960398

SO-VID: 73133f94-83bf-4a51-82f8-90c229e7caf6

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