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      Síntesis de análogos de 7-cloro-N-(3-fenilsustituido)-4- aminoquinolina con posible actividad antin Translated title: Synthesis of 7-chloro-N-(3-phenylsubstituted)-4- aminoquinoline analogs with possible antineoplastic activity

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          Abstract

          Una serie de derivados del 7-cloro-N-(3-fenilsustituido)-4-aminoquinolina fueron sintetizados y evaluados como posibles agentes antineoplásicos, midiendo los efectos citotóxicos en líneas celulares del tipo PC-3 (células tumorales de próstata humana), MCF-7 (adenocarcinoma de mama) y una línea celular no tumoral VERO (constituida por células epiteliales de riñón de mono verde africano) como control. El compuesto más activo fue 7-cloro-N-(3-hidroxifenil)-4-aminoquinolina (1), el cual posee un grupo hidroxilo; sin embargo, el mismo no logró actuar selectivamente sobre las células tumorales y normales. Los derivados fueron caracterizados a través de su punto de fusión y empleando técnicas espectroscópicas (RMN 1H 1D e IR).

          Translated abstract

          A series of 7-chloro-N-(3-phenylsubstituted)-4-aminoquinoline derivatives were synthesized and evaluated as possible antineoplastic agents, measuring cytotoxic effects in PC-3 cell lines (human prostate tumor cells), MCF-7 (breast adenocarcinoma) and a non-tumorigenic VERO cell line (constituted by African green monkey kidney epithelial cells) as a control. The most active compound was 7-chloro-N-(3- hidroxyphenyl)-4-aminoquinoline (1), which has a hydroxyl group; however, it failed to selectively act on tumor and normal cells. The derivatives were characterized by their melting point and employing spectroscopic techniques (1H NMR 1D and IR).

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          El proyecto de Investigación

          F.G Arias (1997)
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            Author and article information

            Contributors
            Role: ND
            Role: ND
            Role: ND
            Journal
            ri
            Revista de Investigación
            Revista de Investigación
            2009.Instituto Pedagógico de Caracas. Universidad Pedagógica Experimental Libertador (Caracas, Distrito Capital, Venezuela )
            1010-2914
            April 2017
            : 41
            : 90
            : 155-178
            Affiliations
            [01] orgnameUniversidad Pedagógica Experimental Libertador orgdiv1Instituto Pedagógico de Caracas Venezuela hegira_01hotmail.com arthurbarazarte@ 123456gmail.com
            [02] orgnameUniversidad Central de Venezuela Venezuela harris.jaime@ 123456gmail.com
            Article
            S1010-29142017000100011
            7330de2f-78c6-415d-89d7-d687712dfdf6

            http://creativecommons.org/licenses/by/4.0/

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            Figures: 0, Tables: 0, Equations: 0, References: 2, Pages: 24
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            SciELO Venezuela


            cáncer,antineoplásicos,Quinoline,synthesis,cancer,antineoplastic,Quinolina,síntesis

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