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      Associations of circulating chemerin and adiponectin concentrations with hepatic steatosis

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          Abstract

          Objective

          Chemerin and adiponectin are adipokines assumed to be involved in the development of metabolic syndrome-related phenotypes like hepatic steatosis. We aimed to evaluate the associations of circulating chemerin and adiponectin concentrations with liver enzymes, liver fat content, and hepatic steatosis in the general population.

          Methods

          Data of 3951 subjects from the population-based Study of Health in Pomerania (SHIP-TREND) were used. Hepatic steatosis was assumed when either a hyperechogenic liver (assessed via ultrasound) or a magnetic resonance imaging (MRI)-quantified liver fat content >5% was present. Adjusted sex-specific quantile and logistic regression models were applied to analyze the associations of chemerin and adiponectin with liver enzymes, liver fat content and hepatic steatosis.

          Results

          The observed associations of chemerin and adiponectin with liver enzymes were very divergent depending on sex, fasting status and the specific enzyme. More consistent results were seen in the analyses of these adipokines in relation to MRI-quantified liver fat content. Here, we observed inverse associations to adiponectin in both sexes as well as a positive (men) or U-shaped (women) association to chemerin. Similarly, the MRI-based definition of hepatic steatosis revealed strongly consistent results: in both sexes, high chemerin concentrations were associated with higher odds of hepatic steatosis, whereas high adiponectin concentrations were associated with lower odds.

          Conclusion

          Our results suggest a role of these adipokines in the pathogenesis of hepatic steatosis independent of metabolic or inflammatory disorders. However, experimental studies are needed to further clarify the underlying mechanisms and the inter-play between adipokine concentrations and hepatic steatosis.

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          Most cited references 45

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          Nonalcoholic fatty liver disease.

           Paul Angulo (2002)
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            Cohort profile: the study of health in Pomerania.

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              Chemerin is a novel adipokine associated with obesity and metabolic syndrome.

              Soluble protein hormones are key regulators of a number of metabolic processes, including food intake and insulin sensitivity. We have used a signal sequence trap to identify genes that encode secreted or membrane-bound proteins in Psammomys obesus, an animal model of obesity and type 2 diabetes (T2D). Using this signal sequence trap, we identified the chemokine chemerin as being a novel adipokine. Gene expression of chemerin and its receptor, chemokine-like receptor 1 (CMKLR1), was significantly higher in adipose tissue of obese and type 2 diabetic P. obesus compared with lean, normoglycemic P. obesus. Fractionation of P. obesus adipose tissue confirmed that chemerin was predominantly expressed in adipocytes, whereas CMKLR1 was expressed in both adipocytes and stromal-vascular cells of adipose tissue. In 3T3-L1 adipocytes, chemerin was markedly induced during differentiation, whereas CMKLR1 was down-regulated during differentiation. Serum chemerin levels were measured by ELISA in human plasma samples from 114 subjects with T2D and 142 normal glucose tolerant controls. Plasma chemerin levels were not significantly different between subjects with T2D and normal controls. However, in normal glucose tolerant subjects, plasma chemerin levels were significantly associated with body mass index, circulating triglycerides, and blood pressure. Here we report, for the first time, that chemerin is an adipokine, and circulating levels of chemerin are associated with several key aspects of metabolic syndrome.
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                Author and article information

                Journal
                Endocr Connect
                Endocr Connect
                EC
                Endocrine Connections
                Bioscientifica Ltd (Bristol )
                2049-3614
                August 2019
                02 July 2019
                : 8
                : 8
                : 1097-1107
                Affiliations
                [1 ]Institute of Clinical Chemistry and Laboratory Medicine , University Medicine Greifswald, Greifswald, Germany
                [2 ]Institute for Community Medicine , University Medicine Greifswald, Greifswald, Germany
                [3 ]DZHK (German Centre for Cardiovascular Research) , Greifswald, Germany
                [4 ]DZD (German Center for Diabetes Research) , Greifswald, Germany
                [5 ]Department of Medicine A , University Medicine Greifswald, Greifswald, Germany
                [6 ]Department of Diagnostic Radiology and Neuroradiology , University Medicine Greifswald, Greifswald, Germany
                [7 ]Institute and Policlinic for Radiology and Interventional Radiology , University Hospital, Carl-Gustav-Carus University Dresden, Dresden, Germany
                Author notes
                Correspondence should be addressed to S Zylla: stephanie.zylla@ 123456med.uni-greifswald.de
                Article
                EC-19-0300
                10.1530/EC-19-0300
                6652250
                31265993
                © 2019 The authors

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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