3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6).

      Biochemical and Biophysical Research Communications
      3' Untranslated Regions, genetics, Animals, Blotting, Western, Cell Line, Tumor, Cell Proliferation, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Male, Mice, Mice, Inbred BALB C, Mice, Nude, MicroRNAs, Mutation, Oligonucleotide Array Sequence Analysis, Prostatic Neoplasms, metabolism, pathology, Prostatic Neoplasms, Castration-Resistant, RNA Interference, Reverse Transcriptase Polymerase Chain Reaction, STAT6 Transcription Factor, Tumor Suppressor Proteins, Xenograft Model Antitumor Assays, bcl-X Protein

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Castration-resistant prostate cancer (CRPC), whose pathogenesis is known to be regulated by microRNAs (miRNAs), has a poor prognosis. In our present study, we found that the expression of miR-361-5p in CRPC was lower than in androgen-dependent prostate cancer (ADPC), indicating that miR-361-5p may play an important role in the progression of ADPC to CRPC. The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date. Our findings suggest that miR-361-5p is a suppressor in CRPC. Signal transducer and activator of transcription-6 (STAT6), a direct target of miR-361-5p, enhances the expression of B-cell lymphoma-extra large (Bcl-xL), while miR-361-5p inhibits its expression through STAT6. Therefore, miR-361-5p has great clinical significance in preventing the malignant progression of PCa. Copyright © 2014 Elsevier Inc. All rights reserved.

          Related collections

          Author and article information

          Comments

          Comment on this article