Compostos químicos isolados de extratos e óleos essenciais do gênero Zanthoxylum Linnaeus (Rutaceae) e seu potencial antimicrobiano

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Abstract

RESUMO Este artigo de revisão reporta ao estudo químico e farmacológico de metabolitos secundários isolados de 20 espécies do gênero Zanthoxylum Linnaeus. Os constituintes químicos voláteis e fixos das espécies desse gênero foram isolados e caracterizados por métodos analíticos. Esta revisão foi realizada através da busca organizada de Dissertações de Mestrado, Teses de Doutorado e principalmente artigos científicos publicados sobre estudos fotoquímicos e atividades antimicrobianas das espécies do gênero Zanthoxylum disponíveis nos Periódicos CAPES, PubMed, ScienceDirect, Scopus, Scielo e Google Acadêmico entre 1985 e 2019. As espécies apresentaram composição química diversificada onde predominam alcaloides, terpenos e cumarinas com diferentes tipos de atividades antimicrobianas, tais como: antifúngica, antibiótica, antiprotozoário e antiviral.

Translated abstract

ABSTRACT This review covers the documentation of the isolated and biologically active chemical constituents of 20 species of the genus Zanthoxylum Linnaeus distributed all over the world. The species extracts and oils chemical constituents were isolated and characterized by different analytical methods. This review was carried out through the survey of the Master’s Dissertations, Doctoral Theses and mainly published scientific articles about the biological activity and phytochemical characterization of Zanthoxylum species, available at in the CAPES, PubMed, ScienceDirect, Scopus, Scielo and Google Scholar databases from 1985 to 2019. The species presented a diverse chemical composition in which alkaloids, terpenes and coumarins predominate. In addition, those chemical compounds perform different types of biological activity for the plant, such as larvicidal, anti-inflammatory, analgesic, antinociceptive, antioxidant, antibiotic, hepatoprotective, antiplasmodial, cytotoxic, antiproliferative, anthelmintic, antiviral and antifungal.

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Persistence and adherence with topical glaucoma therapy.

Beth Nordstrom, David Friedman, Essy Mozaffari … (2005)

The present study describes the patterns and predictors of treatment persistence and adherence among patients who are diagnosed with glaucoma or as glaucoma suspects (based on claims codes). A retrospective cohort study using health insurance claims data. Newly treated individuals with diagnosed glaucoma (n = 3623) and suspect glaucoma (n = 1677) were obtained from healthcare claims data in the Ingenix Research Database. For each of these two diagnostic groups, we calculated the duration of continuous treatment with the initially prescribed medication (persistence) and the prevalence of use of the initial medication at various time points (adherence). Four drug classes were included: beta-blockers, alpha-agonists, carbonic anhydrase inhibitors, and prostaglandin analogs. Nearly one half of the individuals who had filled a glaucoma prescription discontinued all topical ocular hypotensive therapy within six months, and just 37% of these individuals recently had refilled their initial medication at three years after the first dispensing. Prostaglandins were associated with better persistence than any other drug class, which was indicated by hazard ratios for discontinuation of prostaglandins compared with beta-blockers of 0.40 (95% confidence interval, 0.35-0.44) for diagnosed patients and 0.44 (95% confidence interval, 0.37-0.52) for patients with suspect glaucoma. Prostaglandins showed a similar advantage in adherence. Furthermore, patients with diagnosed glaucoma were more likely to adhere to therapy than patients with suspect glaucoma (relative risk = 1.11; 95% confidence interval, 1.05-1.18). Persistence and adherence were substantially better with prostaglandins than with other drug classes, and patients with diagnosed open-angle glaucoma were more likely to adhere to treatment than suspected glaucoma.

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Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities

Weng-Keong Chan, Loh Teng-Hern Tan, Kok-Gan Chan … (2016)

Nerolidol (3,7,11-trimethyl-1,6,10-dodecatrien-3-ol) is a naturally occurring sesquiterpene alcohol that is present in various plants with a floral odor. It is synthesized as an intermediate in the production of (3E)-4,8-dimethy-1,3,7-nonatriene (DMNT), a herbivore-induced volatile that protects plants from herbivore damage. Chemically, nerolidol exists in two geometric isomers, a trans and a cis form. The usage of nerolidol is widespread across different industries. It has been widely used in cosmetics (e.g., shampoos and perfumes) and in non-cosmetic products (e.g., detergents and cleansers). In fact, U.S. Food and Drug Administration (FDA) has also permitted the use of nerolidol as a food flavoring agent. The fact that nerolidol is a common ingredient in many products has attracted researchers to explore more medicinal properties of nerolidol that may exert beneficial effect on human health. Therefore, the aim of this review is to compile and consolidate the data on the various pharmacological and biological activities displayed by nerolidol. Furthermore, this review also includes pharmacokinetic and toxicological studies of nerolidol. In summary, the various pharmacological and biological activities demonstrated in this review highlight the prospects of nerolidol as a promising chemical or drug candidate in the field of agriculture and medicine.

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Compliance barriers in glaucoma: a systematic classification.

James Pichert, Plinio S. Ramos, Katrina McClure … (2003)

To systematically identify and describe common obstacles to medication adherence (i.e., compliance) for patients with glaucoma. A prospective case series of structured interviews were conducted with 48 patients with glaucoma. The subjects' responses were recorded verbatim on interview forms as well as recorded on audiotapes. Situational obstacles to medication adherence were elicited. Using hierarchical cluster analysis, the situational descriptions were stratified, grouped, and analyzed by frequency distribution. Seventy-one unique situational obstacles were reported. These were then grouped into 4 defined and separate categories: situational/environmental factors (35 of 71 situations; 49%), medication regimen (23 of 71; 32%), patient factors (11 of 71; 16%), and provider factors (2 of 71; 3%). Significant barriers to compliance exist for patients with glaucoma in addition to those cited by previous ophthalmic studies. A systematic classification (i.e., taxonomy) of these barriers was formulated to assist in optimizing patient education and problem-solving regarding prescribed therapeutic regimens.

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Journal

Journal ID (publisher-id): hoehnea

Title: Hoehnea

Abbreviated Title: Hoehnea

Publisher: Instituto de Botânica (São Paulo, SP, Brazil )

ISSN (Print): 0073-2877

ISSN (Electronic): 2236-8906

Publication date (Print and electronic): 2020

Volume: 47

Electronic Location Identifier: e882019

Affiliations

[3] Sobral CE orgnameUniversidade Estadual Vale do Acaraú orgdiv1Laboratório de Química de Produtos Naturais, Síntese e Biocatálise de Compostos Orgânicos Brasil

[4] Sobral CE orgnameUniversidade Estadual Vale do Acaraú orgdiv1Departamento de Ciências Biológicas orgdiv2Laboratório de Microbiologia Brasil

[2] Morada Nova CE orgnameInstituto Federal de Ciências e Tecnologia do Ceará Brasil

[1] Fortaleza Ceará orgnameUniversidade Estadual do Ceará Brazil

Article

Publisher ID: S2236-89062020000100226 Publisher ID: S2236-8906(20)04700000226

DOI: 10.1590/2236-8906-88/2019

SO-VID: 7348d037-27ff-4d81-b3e0-53b1a31fbb7b

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This work is licensed under a Creative Commons Attribution 4.0 International License.

History

Date received : 27 September 2019

Date accepted : 11 December 2019

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Figures: 0, Tables: 0, Equations: 0, References: 160, Pages: 0

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Compostos químicos isolados de extratos e óleos essenciais do gênero Zanthoxylum Linnaeus (Rutaceae) e seu potencial antimicrobiano Translated title: Chemical compounds isolated from extracts and essential oils of the genus Zanthoxylum Linnaeus (Rutaceae) and its antimicrobial potential

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Most cited references 141

Persistence and adherence with topical glaucoma therapy.

Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities

Compliance barriers in glaucoma: a systematic classification.

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