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      Living with opioids: A qualitative study with patients with chronic low back pain

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          Abstract

          Background

          Opioids are one of the most prescribed treatments for chronic pain (CP). However, their long‐term use (>3 months) has been surrounded by controversy, due to loss of beneficial effects.

          Objective

          To explore the experiences of people with chronic non‐malignant low back pain in Spain undergoing long‐term treatment with opioids.

          Design

          Qualitative study.

          Setting and participants

          We conducted 15 semi‐structured interviews at the Pain Clinic with persons taking opioid treatment.

          Methods

          The interviews were analysed by qualitative content analysis as described by Graneheim and Lundman, and developed categories and themes discussed in light of a biomedicalization framework.

          Main results

          We developed one overarching theme— Living with opioids: dependence and autonomy while seeking relief—and three categories: The long pathway to opioids due to the invisibility of pain; Opioids: from blind date to a long‐term relationship ; and What opioids cannot fix.

          Discussion

          The long and difficult road to find effective treatments was a fundamental part of coping with pain, involving long‐term relationships with the health system. This study reflects the benefits, and drawbacks of opioids, along with struggles to maintain autonomy and make decisions while undergoing long‐term treatment with opioids. The paper also highlights the consequences of pain in the economy, family and social life of patients.

          Conclusions

          Patients' experiences should be considered to a greater extent by health‐care professionals when giving information about opioids and setting treatment goals. Greater consideration of the social determinants of health that affect CP experiences might lead to more effective solutions to CP.

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          Most cited references52

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          Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness.

          Qualitative content analysis as described in published literature shows conflicting opinions and unsolved issues regarding meaning and use of concepts, procedures and interpretation. This paper provides an overview of important concepts (manifest and latent content, unit of analysis, meaning unit, condensation, abstraction, content area, code, category and theme) related to qualitative content analysis; illustrates the use of concepts related to the research procedure; and proposes measures to achieve trustworthiness (credibility, dependability and transferability) throughout the steps of the research procedure. Interpretation in qualitative content analysis is discussed in light of Watzlawick et al.'s [Pragmatics of Human Communication. A Study of Interactional Patterns, Pathologies and Paradoxes. W.W. Norton & Company, New York, London] theory of communication.
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            Opioids in chronic non-cancer pain: systematic review of efficacy and safety.

            Opioids are used increasingly for chronic non-cancer pain. Controversy exists about their effectiveness and safety with long-term use. We analysed available randomised, placebo-controlled trials of WHO step 3 opioids for efficacy and safety in chronic non-cancer pain. The Oxford Pain Relief Database (1950-1994) and Medline, EMBASE and the Cochrane Library were searched until September 2003. Inclusion criteria were randomised comparisons of WHO step 3 opioids with placebo in chronic non-cancer pain. Double-blind studies reporting on pain intensity outcomes using validated pain scales were included. Fifteen randomised placebo-controlled trials were included. Four investigations with 120 patients studied intravenous opioid testing. Eleven studies (1025 patients) compared oral opioids with placebo for four days to eight weeks. Six of the 15 included trials had an open label follow-up of 6-24 months. The mean decrease in pain intensity in most studies was at least 30% with opioids and was comparable in neuropathic and musculoskeletal pain. About 80% of patients experienced at least one adverse event, with constipation (41%), nausea (32%) and somnolence (29%) being most common. Only 44% of 388 patients on open label treatments were still on opioids after therapy for between 7 and 24 months. The short-term efficacy of opioids was good in both neuropathic and musculoskeletal pain conditions. However, only a minority of patients in these studies went on to long-term management with opioids. The small number of selected patients and the short follow-ups do not allow conclusions concerning problems such as tolerance and addiction.
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              A review of chronic pain impact on patients, their social environment and the health care system

              Chronic pain (CP) seriously affects the patient’s daily activities and quality of life, but few studies on CP have considered its effects on the patient’s social and family environment. In this work, through a review of the literature, we assessed several aspects of how CP influences the patient’s daily activities and quality of life, as well as its repercussions in the workplace, and on the family and social environment. Finally, the consequences of pain on the health care system are discussed. On the basis of the results, we concluded that in addition to the serious consequences on the patient’s life, CP has a severe detrimental effect on their social and family environment, as well as on health care services. Thus, we want to emphasize on the need to adopt a multidisciplinary approach to treatment so as to obtain more comprehensive improvements for patients in familial and social contexts. Accordingly, it would be beneficial to promote more social- and family-oriented research initiatives.
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                Author and article information

                Contributors
                Role: PhD Studenthelena.desolaperea@alum.uca.es
                Role: Assistant Lecturer
                Role: Professor
                Role: Assistant Lecturer
                Role: Professor
                Journal
                Health Expect
                Health Expect
                10.1111/(ISSN)1369-7625
                HEX
                Health Expectations : An International Journal of Public Participation in Health Care and Health Policy
                John Wiley and Sons Inc. (Hoboken )
                1369-6513
                1369-7625
                18 June 2020
                October 2020
                : 23
                : 5 ( doiID: 10.1111/hex.v23.5 )
                : 1118-1128
                Affiliations
                [ 1 ] The Observatory of Pain University of Cádiz Cádiz Spain
                [ 2 ] Biomedical Research and Innovation Institute of Cádiz (INiBICA) Cádiz Spain
                [ 3 ] Preventive Medicine and Public Health Area Cádiz Spain
                [ 4 ] Department of Nursing I, Faculty of Medicine and Nursing University of the Basque Country UPV/EHU Leioa Bizkaia Spain
                [ 5 ] Department of Statistics and Operational Research University of Cádiz Cádiz Spain
                [ 6 ] Department of Epidemiology and Global Health Umeå University Umeå Sweden
                Author notes
                [*] [* ] Correspondence

                Helena De Sola, Preventive Medicine and Public Health Area, University of Cádiz, Avenida Ana de Viya, 52, 11009 Cádiz, Spain.

                Email: helena.desolaperea@ 123456alum.uca.es

                Author information
                https://orcid.org/0000-0003-0196-4875
                https://orcid.org/0000-0002-8256-5771
                https://orcid.org/0000-0002-6603-3054
                https://orcid.org/0000-0001-9567-462X
                https://orcid.org/0000-0002-8114-4705
                Article
                HEX13089
                10.1111/hex.13089
                7696128
                32558064
                734f3ecf-b8dd-485e-adbe-2b707b6b9425
                © 2020 The Authors Health Expectations published by John Wiley & Sons Ltd

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 05 December 2019
                : 16 May 2020
                : 19 May 2020
                Page count
                Figures: 0, Tables: 3, Pages: 11, Words: 9640
                Categories
                Original Research Paper
                Original Research Papers
                Custom metadata
                2.0
                October 2020
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.9.4 mode:remove_FC converted:28.11.2020

                Health & Social care
                biomedicalization,chronic pain,experience,low back pain,opioid,treatment
                Health & Social care
                biomedicalization, chronic pain, experience, low back pain, opioid, treatment

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