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      Correlation of L-myc RFLP with metastasis, prognosis and multiple cancer in lung-cancer patients.

      International Journal of Cancer. Journal International du Cancer
      Combined Modality Therapy, Genes, myc, Humans, Lung Neoplasms, genetics, pathology, therapy, Lymphatic Metastasis, Neoplasm Metastasis, Neoplasms, Multiple Primary, Polymorphism, Restriction Fragment Length, Prognosis, Proto-Oncogene Proteins c-myc, Sex Factors, Smoking, Survival Analysis

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          Abstract

          For further study of the correlation of L-myc restriction-fragment-length polymorphism (RFLP) and metastasis of lung cancer to lymph nodes or other organs at the time of surgery, L-myc RFLP was analyzed in 252 Japanese lung-cancer patients. A close correlation between L-myc RFLP and metastasis was confirmed in this large number of patients (p = 0.01). The correlation was particularly pronounced in cases of adenocarcinoma and squamous-cell carcinoma. Poor prognosis (additional metastases after surgery) was observed in lung-cancer patients with L-S (identified as long and short bands produced with EcoRI) and S-S type L-myc RFLP. In addition, the death rate of lung-cancer patients with the L-S and S-S types was greater than that of those with the L-L type. Lung-cancer patients of the L-S and S-S types had almost 4 times higher incidence of multiple cancer in the lung, pharynx and other organs than those with the L-L type. Our results indicate that, in patients with lung cancer, genetic disposition with respect to the L-myc gene influences the extent of metastasis, the incidence of multiple cancers and prognosis.

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