Blog
About

6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      A P2X purinoceptor expressed by a subset of sensory neurons.

      Nature

      Xenopus, Amino Acid Sequence, Sequence Homology, Amino Acid, Receptors, Purinergic P2X3, genetics, biosynthesis, Receptors, Purinergic P2, Rats, PC12 Cells, Oocytes, metabolism, Neurons, Afferent, Molecular Sequence Data, In Situ Hybridization, Electrophysiology, Cloning, Molecular, Cells, Cultured, Cell Line, Blotting, Northern, Animals

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          ATP is known to depolarize sensory neurons, and may play a role in nociceptor activation when released from damaged tissue. Here we report the molecular cloning and characterization of a new member of the P2X receptor family, P2X3, expressed by these cells. The channel transcript was present in a subset of rat dorsal-root-ganglion sensory neurons, some of which express nociceptor-associated markers; it was absent in other tissues that were tested, including sympathetic, enteric and central nervous system neurons. Moreover, when expressed in Xenopus oocytes, the channel showed an ATP-dependent cation flux. P2X3 is the only ligand-gated channel known to be expressed exclusively by a subset of sensory neurons. The remarkable selectivity of expression of the channel coupled with its sensory neuron-like pharmacology suggests that this channel may transduce ATP-evoked nociceptor activation.

          Related collections

          Author and article information

          Journal
          10.1038/377428a0
          7566119

          Comments

          Comment on this article