For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
6
views
25
references
 Top references
cited by
4
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      199
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Combination of alcohol and glucose consumption as a risk to induce reactive hypoglycemia

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Aims/Introduction

          Alcohol consumption has been reported to cause hypoglycemia. However, the mechanism involved has not been unequivocally established. This study comprised healthy volunteers. We carried out a prospective trial to compare the effects of glucose and alcohol consumption, alone or in combination, on glucose and lipid metabolism.

          Materials and Methods

          A 75‐g oral glucose tolerance test (OGTT), a combined 75‐g glucose plus 20‐g alcohol tolerance test (OGATT) and a 20‐g alcohol tolerance test (OATT) were carried out in the participants. Plasma glucose, insulin, triglyceride and ethanol concentrations during each test were compared.

          Results

          We studied 10 participants. Their plasma glucose concentrations 15 and 30 min after the intake of 75 g of glucose were significantly higher during the OGATT than the OGTT. Hypoglycemia occurred in five participants after the OGATT, which was significantly more frequently than after the OGTT ( P = 0.046). Hypoglycemia did not occur after the OATT, and the ethanol concentration was significantly lower after the OGATT than the OATT. The changes in triglyceride concentration from 30 min after the consumption of 75 g of glucose were significantly greater during the OGATT than the OGTT. The plasma insulin concentrations peaked after 60 min during both the OGTT and OGATT, and were significantly higher during the OGATT ( P = 0.047). There were no differences between the two interventions in the Matsuda or disposition indexes.

          Conclusions

          Hypoglycemia occurred more frequently after the simultaneous consumption of alcohol plus glucose than after the consumption of glucose alone, suggesting that alcohol in the combination of glucose induces reactive hypoglycemia.

          Abstract

          Hypoglycemia occurred more frequently following the simultaneous ingestion of alcohol plus glucose than following the ingestion of glucose alone, suggesting that alcohol in the combination of glucose induces reactive hypoglycemia.

          Related collections

          Most cited references25

          • Record: found
          • Abstract: found
          • Article: not found

          Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

          M. Matsuda, R DeFronzo (1999)
          Several methods have been proposed to evaluate insulin sensitivity from the data obtained from the oral glucose tolerance test (OGTT). However, the validity of these indices has not been rigorously evaluated by comparing them with the direct measurement of insulin sensitivity obtained with the euglycemic insulin clamp technique. In this study, we compare various insulin sensitivity indices derived from the OGTT with whole-body insulin sensitivity measured by the euglycemic insulin clamp technique. In this study, 153 subjects (66 men and 87 women, aged 18-71 years, BMI 20-65 kg/m2) with varying degrees of glucose tolerance (62 subjects with normal glucose tolerance, 31 subjects with impaired glucose tolerance, and 60 subjects with type 2 diabetes) were studied. After a 10-h overnight fast, all subjects underwent, in random order, a 75-g OGTT and a euglycemic insulin clamp, which was performed with the infusion of [3-3H]glucose. The indices of insulin sensitivity derived from OGTT data and the euglycemic insulin clamp were compared by correlation analysis. The mean plasma glucose concentration divided by the mean plasma insulin concentration during the OGTT displayed no correlation with the rate of whole-body glucose disposal during the euglycemic insulin clamp (r = -0.02, NS). From the OGTT, we developed an index of whole-body insulin sensitivity (10,000/square root of [fasting glucose x fasting insulin] x [mean glucose x mean insulin during OGTT]), which is highly correlated (r = 0.73, P < 0.0001) with the rate of whole-body glucose disposal during the euglycemic insulin clamp. Previous methods used to derive an index of insulin sensitivity from the OGTT have relied on the ratio of plasma glucose to insulin concentration during the OGTT. Our results demonstrate the limitations of such an approach. We have derived a novel estimate of insulin sensitivity that is simple to calculate and provides a reasonable approximation of whole-body insulin sensitivity from the OGTT.
          Article 0 comments Cited 952 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Alcohol consumption and blood pressure Kaiser-Permanente Multiphasic Health Examination data.

            A B Siegelaub, Lauren G Friedman, A Klatsky … (1977)
            We studied blood pressure in relation to known drinking habits of 83,947 men and women of three races (83.5 per cent white). Using health-check-up questionnaire responses, we classified persons as nondrinkers or according to usual daily number of drinks: two or fewer per day, three to five per day, or six or more per day. As compared to nondrinkers blood pressures of men taking two or fewer drinks per day were similar. Women who took two or fewer drinks per day had slightly lower pressures. Men and women who took three or more drinks per day had higher systolic pressures (P less than 10(-24) in white men, and less than 10(-12) in white women), higher diastolic pressures (P less than 10(-24) in white men, and less than 10(-6) in white women), and substantially higher prevalence of pressures greater than or equal to 160/95 mm Hg. The associations of blood pressure and drinking were independent of age, sex, race, smoking, coffee use, former "heavy" drinking, educational attainment and adiposity. The findings strongly suggest that regular use of three or more drinks of alcohol per day is a risk factor for hypertension.
            Article 0 comments Cited 73 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Diabetes mellitus and alcohol.

              Albert van de Wiel (2015)
              Alcohol influences glucose metabolism in several ways in diabetic patients as well as in non-diabetic patients. Since alcohol inhibits both gluconeogenesis and glycogenolysis, its acute intake without food may provoke hypoglycaemia, especially in cases of depleted glycogen stores and in combination with sulphonylurea. Consumed with a meal including carbohydrates, it is the preferred fuel, which may initially lead to somewhat higher blood glucose levels and hence an insulin response in type 2 diabetic patients. Depending on the nature of the carbohydrates in the meal, this may be followed by reactive hypoglycaemia. Moderate consumption of alcohol is associated with a reduced risk of atherosclerotic disorders. Diabetic patients benefit from this favourable effect as much as non-diabetic patients. Apart from effects on lipid metabolism, haemostatic balance and blood pressure, alcohol improves insulin sensitivity. This improvement of insulin sensitivity may also be responsible for the lower incidence of type 2 diabetes mellitus reported to be associated with light-to-moderate drinking. In case of moderate and sensible use, risks of disturbances in glycaemic control, weight and blood pressure are limited. Excessive intake of alcohol, however, may not only cause loss of metabolic control, but also annihilate the favourable effects on the cardiovascular system. Copyright 2004 John Wiley & Sons, Ltd.
              Article 0 comments Cited 40 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Hideaki Miyoshi:
                ORCID: https://orcid.org/0000-0002-5909-3243
                hmiyoshi@med.hokudai.ac.jp
                Journal
                Journal ID (nlm-ta): J Diabetes Investig
                Journal ID (iso-abbrev): J Diabetes Investig
                Journal ID (doi): 10.1111/(ISSN)2040-1124
                Journal ID (publisher-id): JDI
                Title: Journal of Diabetes Investigation
                Publisher: John Wiley and Sons Inc. (Hoboken )
                ISSN (Print): 2040-1116
                ISSN (Electronic): 2040-1124
                Publication date (Electronic): 07 September 2020
                Publication date (Print): April 2021
                Volume: 12
                Issue: 4 ( doiID: 10.1111/jdi.v12.4 )
                Pages: 651-657
                Affiliations
                [ 1 ] Sapporo Diabetes and Thyroid Clinic Sapporo Japan
                [ 2 ] Department of Rheumatology, Endocrinology, and Nephrology Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan
                [ 3 ] Clinical Research and Medical Innovation Center Hokkaido University Sapporo Japan
                [ 4 ] Division of Diabetes and Obesity Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan
                Author notes
                [*] [* ] Correspondence

                Hideaki Miyoshi

                Tel.: +81‐11‐706‐5915

                Fax: +81‐11‐706‐7710

                E‐mail address: hmiyoshi@ 123456med.hokudai.ac.jp

                Author information
                https://orcid.org/0000-0002-8192-0006
                https://orcid.org/0000-0003-0713-221X
                https://orcid.org/0000-0003-1870-6688
                https://orcid.org/0000-0002-3131-0832
                https://orcid.org/0000-0002-5909-3243
                Article
                Publisher ID: JDI13375
                DOI: 10.1111/jdi.13375
                PMC ID: 8015820
                PubMed ID: 33448697
                SO-VID: 7380c8c1-e9de-41fe-9d15-8d859b395fcf
                Copyright © © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

                History
                Date revision received : 07 June 2020
                Date received : 01 March 2020
                Date accepted : 21 July 2020
                Page count
                Figures: 3, Tables: 4, Pages: 7, Words: 4760
                Categories
                Subject: Original Article
                Subject: Articles
                Subject: Clinical Science and Care
                Custom metadata
                source-schema-version-number 2.0
                cover-date April 2021
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:6.0.1 mode:remove_FC converted:01.04.2021

                Keywords: alcohol,hypoglycemia,oral glucose tolerance test
                Data availability:
                Keywords: alcohol, hypoglycemia, oral glucose tolerance test

                Comments

                Comment on this article

                scite_

                Similar content199

                See all similar

                Cited by4

                See all cited by

                Most referenced authors311

                See all reference authors