Blog
About

  • Record: found
  • Abstract: found
  • Article: found
Is Open Access

Erodible Film Formulation for Potential Ocular Drug Delivery

Read this article at

ScienceOpenPublisher
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Summary

      Drug delivery to the eye has always been an interesting and challenging field in pharmaceutical formulation and drug design. The aim of this research was the formulation development of thin erodible films for potential delivery of lopidine to treat glaucoma. Films were prepared using hyaluronic acid (HA) and hydroxypropyl methylcellulose (HPMC) as polymers, together with glycerol (GLY) as plasticiser. Single layer films were prepared using each polymer individually, as well as in combination to obtain composite thin films. Various combinations and concentrations were optimised to reach the desired transparency, which were then characterised for their physico-chemical and mechanical properties. The following ratios were selected for drug loading: 2% HPMC, 1% HA, 1% composite (HPMC 1:1 HA) and 2% composite (HPMC 1.5:0.5 HA) with all of them containing a ratio of 2:1 polymer to plasticiser.

      Related collections

      Author and article information

      Affiliations
      Department of Pharmaceutical, Chemical and Environmental Sciences, Faculty of Engineering and Science, University of Greenwich, Medway Campus, Kent ME4 4TB, UK.
      Author notes
      *Corresponding author. Tel.: +44 2083 318 980 E-mail: j.s.boateng@123456gre.ac.uk
      Journal
      BJPharm
      British Journal of Pharmacy
      University of Huddersfield Press
      2058-8356
      11 July 2018
      : 2
      : 2 , Proceedings of the 8th APS International PharmSci 2017
      : S29-S30
      10.5920/bjpharm.2017.23
      © 2017, M.A. Tighsazzadeh, J.S. Boateng

      This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0 https://creativecommons.org/licenses/by/4.0/.

      Product
      ScienceOpen disciplines:
      Keywords:

      Comments

      Comment on this article