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      The incidence of acute kidney injury in patients with traumatic brain injury

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      , , ,
      Intensive Care Medicine Experimental
      Springer International Publishing
      ESICM LIVES 2015
      3-7 October 2015

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          Abstract

          Intr There are a few researches that investigated non-neurological complications in traumatic brain injury (TBI) and reported a low incidence of acute kidney injury(AKI). Probably most of them did not use the scores validated for AKI ,likely only identify patients with severe AKI. Objectives The aim of this study was to determine the incidence of AKI using a reliable score as classified by the RIFLE criteria. Methods We study all patients, 16 years and over ,with moderate or severeTBI (Glasgow score < 13) and admitted to the intensive care unit (ICU) in a Trauma Intensive Care Unit Level III (Hospital Cullen) in Santa Fe, Argentina from 1 January 2014 to 31 December 2014. Prospectively collected data of AKI from the ICU trauma registry and pathology database was analyzed retrospectively(Hardinero Quality). Risk injury failure loss end (RIFLE) criteria were used to categorize renal function. Results The incidence of AKI was 17 % (29/169). RIFLE (F10,I5,R13) Patients who developed AKI were older, had higher severity of illness scores, and a lower GCS. ICU mortality : AKI group 58% compared with 30% in patients without AKI. Conclusions In patients with TBI the incidente of AKI is relatively common and identifies patients with a high risk of death. Age, APACHE II and lower Glasgow score identify patients with high risk of AKI.

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          Non-neurologic organ dysfunction in severe traumatic brain injury.

          To describe the incidence of non-neurologic organ dysfunction and its association with outcome in patients with severe traumatic brain injury admitted to intensive care. Observational cohort study. Foothills Medical Centre, which is the only neurosurgical service in southern Alberta (population approximately 1.3 million). Patients were 209 consecutive patients with severe traumatic brain injury. None. Non-neurologic organ dysfunction was measured by the maximum modified multiple organ dysfunction score. Organ system failure was defined as a component score of >/=3 on any day during the patient's intensive care unit stay. One hundred and eighty-five patients (89%) developed dysfunction of at least one non-neurologic organ system. Ninety-six organ system failures were identified in 74 patients (35%). Respiratory failure was the most common non-neurologic organ system failure, occurring in 23% of patients, whereas cardiovascular failure occurred in 18%. Eight patients (4%) had failure of the coagulation system. One patient had renal failure, whereas no patient developed hepatic failure. In a multivariate model, non-neurologic organ dysfunction was independently associated with hospital mortality (odds ratio for hospital mortality, 1.63; 95% confidence interval, 1.34, 1.98 for one maximum modified multiple organ dysfunction score point). Non-neurologic organ dysfunction was also independently associated with dichotomized Glasgow Outcome Score, as a measure of neurologic outcome (odds ratio for unfavorable neurologic outcome, 1.53; 95% confidence interval, 1.22, 1.98 for one maximum modified multiple organ dysfunction score point). The timing of the organ dysfunction did not appear to be important in the prediction of outcome. Non-neurologic organ dysfunction is common in patients with severe traumatic brain injury and is independently associated with worse outcome.
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            The incidence of acute kidney injury in patients with traumatic brain injury.

            There is limited information on the incidence of acute kidney injury (AKI) in patients with traumatic brain injury (TBI) although AKI may contribute to morbidity and mortality. We investigated the incidence of AKI in patients with moderate and severe TBI and the association of AKI with risk factors and outcomes in these patients. We studied all TBI patients over 16 years of age admitted to the two designated trauma hospitals in the state of Victoria, Australia from 1 January to 31 December 2008. Patients were included if they had head trauma and presented with a Glasgow coma scale (GCS) <13. Prospectively collected data from the hospital trauma registries, ICUs, and pathology databases were analyzed retrospectively. Risk injury failure loss end (RIFLE) criteria were used to categorize renal function. The incidence of AKI was 9.2% (19/207). Patients who developed AKI were older, had higher severity of illness scores, and a lower GCS. Overall 42.1% of these patients died in hospital compared with 18.1% in patients without AKI. In univariable linear regression analysis, age, severity of illness, and admitting hospital were associated with AKI. After multivariable logistic regression, the occurrence of AKI was associated with age (p < 0.001) and higher APACHE III scores (p = 0.016). AKI is relatively common even in patients with TBI. Its association with age and APACHE III scores helps identify patients at higher risk of AKI.
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              Author and article information

              Conference
              Intensive Care Med Exp
              Intensive Care Med Exp
              Intensive Care Medicine Experimental
              Springer International Publishing (Cham )
              2197-425X
              1 October 2015
              1 October 2015
              December 2015
              : 3
              Issue : Suppl 1 Issue sponsor : The publication charges for this supplement were funded by Intensive Care Medicine Experimental.
              : A263
              Affiliations
              Hospital Cullen, Santa Fe, Argentina
              Article
              408
              10.1186/2197-425X-3-S1-A263
              4798455
              738d7d0a-92be-4008-8817-ca1081b0454b
              © Avila et al.; 2015

              This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

              ESICM LIVES 2015
              Berlin, Germany
              3-7 October 2015
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              © The Author(s) 2015

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