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Abstract
Fos immunocytochemistry was combined with immunolabeling for dopamine-beta-hydroxylase
(DBH) to examine neuronal activation in the medulla and pons after administration
of polyethelene glycol (PEG), which produces volume depletion without altering arterial
blood pressure. Increased Fos immunoreactivity was observed in the area postrema,
nucleus of the solitary tract, rostral ventrolateral medulla, lateral parabrachial
nucleus, and the dorsomedial pons at the level of the locus coeruleus. Fos immunolabeling
in the caudal nucleus of the solitary tract, rostral ventrolateral medulla, and the
dorsomedial pons occurred primarily in neurons that did not contain DBH. Thus, PEG
activates non-catecholaminergic neurons in medullary and pontine areas associated
with cardiovascular and body fluid regulation.
Copyright 2002 Elsevier Science B.V.