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      Human Renin Granules: Ultrastructural Aspects

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          Abstract

          The ultrastructure of human renin granules has been studied from a case of Bartter’s syndrome. Renin bodies present roundish (R), lobulated (L) or sharply angulated (SA) shapes. The latter are indicative of the highest rates of renin synthesis and thereby of the greatest concentrations of the pressor enzyme. Their singular shape is consistent with the form monoclinic crystals assume when they grow in an isotropic medium. R granules form owing to filling of Golgian vesicles by renin. R bodies may then coalesce for giving rise to transient L forms. Renin is released through leak from the containing granules into the intracellular space.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1983
          1983
          03 December 2008
          : 33
          : 1
          : 29-33
          Affiliations
          aIstituto di Patologia speciale medica e bCentro di Microscopia elettronica, Università di Ferrara; cServizio di Nefrologia e Dialisi, Arcispedale S. Anna, Ferrara, Italia
          Article
          182900 Nephron 1983;33:29–33
          10.1159/000182900
          6339964
          © 1983 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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