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Mixing Acid Salts and Layered Double Hydroxides in Nanoscale under Solid Condition

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Pharmaceutics

MDPI

intercalation, carrier, layered double hydroxide, hydrotalcite

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      Abstract

      The immobilization of potassium sorbate, potassium aspartate and sorbic acid in layered double hydroxide under solid condition was examined. By simply mixing two solids, immobilization of sorbate and aspartate in the interlayer space of nitrate-type layered double hydroxide, so called intercalation reaction, was achieved, and the uptakes, that is, the amount of immobilized salts and the interlayer distances of intercalation compounds were almost the same as those obtained in aqueous solution. However, no intercalation was achieved for sorbic acid. Although intercalation of sorbate and aspartate into chloride-type layered double hydroxide was possible, the uptakes for these intercalation compounds were lower than those obtained using nitrate-type layered double hydroxide. The intercalation under solid condition could be achieved to the same extent as for ion-exchange reaction in aqueous solution, and the reactivity was similar to that observed in aqueous solution. This method will enable the encapsulation of acidic drug in layered double hydroxide as nano level simply by mixing both solids.

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      Most cited references 18

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      Anion-Exchange Properties of Hydrotalcite-Like Compounds

       Shigeo Miyata (1983)
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        Inorganic Layered Double Hydroxides as Nonviral Vectors

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          Intercalative Nanohybrids of Nucleoside Monophosphates and DNA in Layered Metal Hydroxide

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            Author and article information

            Affiliations
            Department of Functional Molecular Chemistry, Kobe Pharmaceutical University, Kobe 658-8558, Japan; E-Mail: ahayashi@ 123456kobepharma-u.ac.jp
            Author notes
            [* ]Author to whom correspondence should be addressed; E-Mail: hiro@ 123456kobepharma-u.ac.jp ; Tel./Fax: +81-78-441-7551.
            Journal
            Pharmaceutics
            Pharmaceutics
            pharmaceutics
            Pharmaceutics
            MDPI
            1999-4923
            30 July 2014
            September 2014
            : 6
            : 3
            : 436-446
            25080007
            4190528
            10.3390/pharmaceutics6030436
            pharmaceutics-06-00436
            © 2014 by the authors; licensee MDPI, Basel, Switzerland.

            This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/3.0/).

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