22
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Self nanoemulsifying drug delivery system (SNEDDS) of rosuvastatin calcium: design, formulation, bioavailability and pharmacokinetic evaluation.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The aim of the present study is to improve solubility and bioavailability of Rosuvastatin calcium using self nanoemulsifying drug delivery system (SNEDDS). Self emulsifying property of various oils including essential oils was evaluated with suitable surfactants and co-surfactants. Ternary phase diagrams were constructed based on Rosuvastatin calcium solubility analysis for optimizing the system. The prepared formulations were evaluated for self emulsifying time, robustness to dilution, droplet size determination and zeta potential analysis. The system was found to be robust in different pH media and dilution volume. The globule size of the optimized system was less than 200nm which could be an acceptable nanoemulsion size range. The zeta potential of the selected CN 7 SNEDDS formulation (cinnamon oil 30%; labrasol 60%; Capmul MCM C8 10%) was -29.5±0.63 with an average particle size distribution of 122nm. In vitro drug release studies showed remarkable increase in dissolution of CN7 SNEDDS compared to marketed formulation. In house developed HPLC method for determination of Rosuvastatin calcium in rat plasma was used in the bioavailability and pharmacokinetic evaluation. The relative bioavailability of self nanoemulsified formulation showed an enhanced bioavailability of 2.45 times greater than that of drug in suspension. The obtained plasma drug concentration data was processed with PKSolver 2.0 and it was best fit into the one compartment model.

          Related collections

          Author and article information

          Journal
          Colloids Surf B Biointerfaces
          Colloids and surfaces. B, Biointerfaces
          Elsevier BV
          1873-4367
          0927-7765
          Dec 01 2013
          : 112
          Affiliations
          [1 ] Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore 641044, Tamil Nadu, India. Electronic address: balakumar_27@yahoo.co.uk.
          Article
          S0927-7765(13)00542-0
          10.1016/j.colsurfb.2013.08.025
          24012665
          73afcded-40da-4a5f-b3f7-1f9bd4cab1a0
          History

          Bioavailability,Pharmacokinetic study,Poorly water soluble drug,Rosuvastatin calcium,SNEDDS,Self nanoemulsifying drug delivery system

          Comments

          Comment on this article