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      Relative Potencies of Human, Rat, Bovine/Caprine, Porcine and Ovine Hypothalamic Growth Hormone-Releasing Factors to Release Growth Hormone by the Rat Anterior Pituitary in vitro

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      S. Karger AG

      Pituitary, Growth hormone, Growth hormone-releasing factor

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          Synthetic rat, human, bovine/caprine, porcine and ovine growth hormone-releasing factor (GRF) were tested for their capacity to release growth hormone (GH) by the rat anterior pituitary in vitro. All peptides elicited parallel and dose-dependent increases in GH release and produced similar maximal GH secretion. Rat GRF was 3–6 times more potent in stimulating the release of GH than all other GRFs, while human, bovine/caprine, porcine and ovine GRF had potencies that were not statistically different. The increased potency of both rat GRF(1–27)NH<sub>2</sub> and rat GRF(1–23)NH<sub>2</sub> when compared to human GRF(1–27)NH<sub>2</sub> and human GRF(1–23)NGH<sub>2</sub>, respectively, suggests that the increased potency of this molecule resides in structural differences in the amino terminal of native GRF. The results demonstrate increased sensitivity of rat pituitary cells for their homologous releasing factor.

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          Author and article information

          S. Karger AG
          01 April 2008
          : 42
          : 4
          : 273-276
          Laboratories for Neuroendocrinology, The Salk Institute for Biological Studies, La Jolla, Calif., USA
          124451 Neuroendocrinology 1986;42:273–276
          © 1986 S. Karger AG, Basel

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          Pages: 4
          Original Paper


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