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      Breast cancer cell lines: friend or foe?

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          Abstract

          The majority of breast cancer research is conducted using established breast cancer cell lines as in vitro models. An alternative is to use cultures established from primary breast tumours. Here, we discuss the pros and cons of using both of these models in translational breast cancer research.

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          Most cited references50

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          A human cell line from a pleural effusion derived from a breast carcinoma.

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            Breast tumor cell lines from pleural effusions.

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              Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization.

              Nineteen human breast carcinoma cell lines have been established as continuous cultures during the past 6 years in our laboratory. This preliminary report is designed to list the lines by their designated code numbers (MDA-MB) and present a brief summary of their morphological, cytogenetic and biochemical characteristics. Sixteen of our lines were obtained from pleural effusions, two from brain metastases, and one from pericardial fluid. All lines have been shown to be distinct entities and are uncontaminated by HeLa cells or each other. A lq marker chromosome is present in all but one of the lines examined.
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                Author and article information

                Journal
                Breast Cancer Res
                Breast Cancer Research
                BioMed Central (London )
                1465-5411
                1465-542X
                2003
                3 February 2003
                : 5
                : 2
                : 89-95
                Affiliations
                [1 ]Molecular Medicine Unit, University of Leeds, Leeds, UK
                [2 ]Breast Unit, St James's University Hospital, Leeds, UK
                [3 ]Academic Unit of Pathology, University of Leeds, Leeds, UK
                Article
                bcr577
                10.1186/bcr577
                154155
                12631387
                73ef3d9e-4ad6-4c4e-b875-ba4d9f1b30a1
                Copyright © 2003 BioMed Central Ltd
                History
                : 8 November 2002
                : 10 January 2003
                : 20 January 2003
                Categories
                Review

                Oncology & Radiotherapy
                mammary gland,cell culture,in vitro models
                Oncology & Radiotherapy
                mammary gland, cell culture, in vitro models

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