Marsha Pellegrino: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Validation
Gianandrea Traversi: Role: Data curationRole: Formal analysisRole: Methodology
Andrea Arena: Role: Formal analysisRole: Visualization
Marco Cappa: Role: InvestigationRole: Resources
M. Manuela Rosado: Role: Data curationRole: Formal analysisRole: Validation
Marco Andreani:
ORCID: http://orcid.org/0000-0003-3451-3624
Role: Methodology
Domenico V. Delfino: Role: Conceptualization
Fabiola Moretti: Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: Writing – review
& editing
Alessandra Fierabracci:
ORCID: http://orcid.org/0000-0003-3078-9754
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: SupervisionRole: ValidationRole:
Writing – original draftRole: Writing – review & editing
Keun Seok Seo: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
29
January
2020
Publication date Collection: 2020
Volume: 15
Issue: 1
Electronic Location Identifier: e0228296
Affiliations
[1
]
Infectivology and Clinical Trials Research Department, Bambino Gesù Children’s Hospital,
IRCCS, Rome, Italy
[2
]
Endocrinology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
[3
]
Research Laboratories, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
[4
]
Transplantation Immunogenetics Laboratory, Bambino Gesù Children’s Hospital, IRCCS,
Rome, Italy
[5
]
Section of Pharmacology, Department of Medicine, University of Perugia, Perugia, Italy
[6
]
Institute of Cell Biology and Neurobiology, National Research Council of Italy (CNR),
Rome, Italy
Mississippi State University, UNITED STATES
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-19-20262
DOI: 10.1371/journal.pone.0228296
PMC ID: 6988923
PubMed ID: 31995625
SO-VID: 73f2888c-2727-4ebf-92df-8bf49ea79e67
Copyright © © 2020 Pellegrino et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: Italian Ministry of Health Ricerca corrente
Award ID: 201802P004265
Award Recipient
:
ORCID: http://orcid.org/0000-0003-3078-9754
Alessandra Fierabracci
Funded by: funder-id http://dx.doi.org/10.13039/501100005010, Associazione Italiana per la Ricerca sul Cancro;
Award ID: IG21814
Award Recipient
:
Fabiola Moretti
AF 201802P004265 Italian Ministry of Health Ricerca Corrente FM IG 21814 AIRC (Associazione
Italiana Ricerca sul Cancro) The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and life sciences
Subject:
Cell biology
Subject:
Cellular types
Subject:
Animal cells
Subject:
Blood cells
Subject:
White blood cells
Subject:
T cells
Subject:
Cytotoxic T cells
Subject:
Biology and life sciences
Subject:
Cell biology
Subject:
Cellular types
Subject:
Animal cells
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Cytotoxic T cells
Subject:
Biology and life sciences
Subject:
Immunology
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Cytotoxic T cells
Subject:
Medicine and health sciences
Subject:
Immunology
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Cytotoxic T cells
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Disorders
Subject:
Diabetes Mellitus
Subject:
Medicine and Health Sciences
Subject:
Metabolic Disorders
Subject:
Diabetes Mellitus
Subject:
Biology and life sciences
Subject:
Cell biology
Subject:
Cellular types
Subject:
Animal cells
Subject:
Blood cells
Subject:
White blood cells
Subject:
T cells
Subject:
Regulatory T cells
Subject:
Biology and life sciences
Subject:
Cell biology
Subject:
Cellular types
Subject:
Animal cells
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Regulatory T cells
Subject:
Biology and life sciences
Subject:
Immunology
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Regulatory T cells
Subject:
Medicine and health sciences
Subject:
Immunology
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Regulatory T cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Artificial Gene Amplification and Extension
Subject:
Polymerase Chain Reaction
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Artificial Gene Amplification and Extension
Subject:
Polymerase Chain Reaction
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Disorders
Subject:
Diabetes Mellitus
Subject:
Type 1 Diabetes
Subject:
Medicine and Health Sciences
Subject:
Metabolic Disorders
Subject:
Diabetes Mellitus
Subject:
Type 1 Diabetes
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Diabetic Endocrinology
Subject:
Insulin
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Hormones
Subject:
Insulin
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
