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      Subthreshold and threshold attention deficit hyperactivity disorder symptoms in childhood: psychosocial outcomes in adolescence in boys and girls

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          Abstract

          Objective

          To examine the association between different levels of childhood attention deficit hyperactivity disorder ( ADHD) symptoms and sex differences in psychosocial outcomes during adolescence.

          Method

          Swedish children ( n = 4635) were screened for neuropsychiatric symptoms at age 9 or 12. ADHD symptoms were divided into three levels: screen‐negative, screen‐intermediate, and screen‐positive. At follow‐up (age 15), parents and teenagers filled out questionnaires regarding (i) hyperactivity/inattention, (ii) peer problems, (iii) school problems, (iv) internalizing problems, (v) antisocial behaviour, (vi) alcohol misuse, and (vii) drug misuse. All outcomes were controlled for symptoms of diagnostic categories other than ADHD.

          Results

          Increasing levels of ADHD symptoms in childhood were associated with higher proportions of adolescents who displayed negative psychosocial outcomes. More girls than boys reported internalizing problems (all levels) and risky drug use (screen‐intermediate and screen‐positive only). More boys reported antisocial behaviour at the screen‐negative and screen‐intermediate levels, but at the screen‐positive level, similar proportions of girls and boys displayed antisocial behaviour.

          Conclusion

          The findings support the view that ADHD symptoms, as well as their negative outcomes, are dimensionally distributed in the population and that adolescent girls and boys display different risk profiles. The findings confirm that ADHD symptoms are associated with higher risk of drug misuse in girls.

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          Most cited references55

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          The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies.

          This study examined the persistence of attention deficit hyperactivity disorder (ADHD) into adulthood. We analyzed data from published follow-up studies of ADHD. To be included in the analysis, these additional studies had to meet the following criteria: the study included a control group and it was clear from the methods if the diagnosis of ADHD included subjects who did not meet full criteria but showed residual and impairing signs of the disorder. We used a meta-analysis regression model to separately assess the syndromatic and symptomatic persistence of ADHD. When we define only those meeting full criteria for ADHD as having 'persistent ADHD', the rate of persistence is low, approximately 15% at age 25 years. But when we include cases consistent with DSM-IV's definition of ADHD in partial remission, the rate of persistence is much higher, approximately 65%. Our results show that estimates of ADHD's persistence rely heavily on how one defines persistence. Yet, regardless of definition, our analyses show that evidence for ADHD lessens with age. More work is needed to determine if this reflects true remission of ADHD symptoms or is due to the developmental insensitivity of diagnostic criteria for the disorder.
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            Attention deficit hyperactivity disorder.

            Attention deficit hyperactivity disorder (ADHD) is a childhood-onset neurodevelopmental disorder with a prevalence of 1·4-3·0%. It is more common in boys than girls. Comorbidity with childhood-onset neurodevelopmental disorders and psychiatric disorders is substantial. ADHD is highly heritable and multifactorial; multiple genes and non-inherited factors contribute to the disorder. Prenatal and perinatal factors have been implicated as risks, but definite causes remain unknown. Most guidelines recommend a stepwise approach to treatment, beginning with non-drug interventions and then moving to pharmacological treatment in those most severely affected. Randomised controlled trials show short-term benefits of stimulant medication and atomoxetine. Meta-analyses of blinded trials of non-drug treatments have not yet proven the efficacy of such interventions. Longitudinal studies of ADHD show heightened risk of multiple mental health and social difficulties as well as premature mortality in adult life.
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              Prospective association of childhood attention-deficit/hyperactivity disorder (ADHD) and substance use and abuse/dependence: a meta-analytic review.

              Given the clinical and public health significance of substance disorders and the need to identify their early risk factors, we examined the association of childhood attention-deficit/hyperactivity disorder (ADHD) with substance use (nicotine, alcohol, marijuana) and abuse/dependence outcomes (nicotine, alcohol, marijuana, cocaine, other). To strengthen a potential causal inference, we meta-analyzed longitudinal studies that prospectively followed children with and without ADHD into adolescence or adulthood. Children with ADHD were significantly more likely to have ever used nicotine and other substances, but not alcohol. Children with ADHD were also more likely to develop disorders of abuse/dependence for nicotine, alcohol, marijuana, cocaine, and other substances (i.e., unspecified). Sex, age, race, publication year, sample source, and version of the Diagnostic and Statistical Manual of Mental Disorders (DSM) used to diagnose ADHD did not significantly moderate the associations with substance outcomes that yielded heterogeneous effect sizes. These findings suggest that children with ADHD are significantly more likely to develop substance use disorders than children without ADHD and that this increased risk is robust to demographic and methodological differences that varied across the studies. Finally, few studies addressed ADHD and comorbid disruptive behavior disorders (DBD), thus preventing a formal meta-analytic review. However, we qualitatively summarize the results of these studies and conclude that comorbid DBD complicates inferences about the specificity of ADHD effects on substance use outcomes. Copyright © 2011 Elsevier Ltd. All rights reserved.
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                Author and article information

                Contributors
                eva.noren@ki.se
                Journal
                Acta Psychiatr Scand
                Acta Psychiatr Scand
                10.1111/(ISSN)1600-0447
                ACPS
                Acta Psychiatrica Scandinavica
                John Wiley and Sons Inc. (Hoboken )
                0001-690X
                1600-0447
                07 October 2016
                December 2016
                : 134
                : 6 ( doiID: 10.1111/acps.2016.134.issue-6 )
                : 533-545
                Affiliations
                [ 1 ] Department of Clinical Neuroscience Centre for Psychiatry Research & EducationKarolinska Institutet & Stockholm County Council StockholmSweden
                [ 2 ] Department of Medical Epidemiology and BiostatisticsKarolinska Institutet StockholmSweden
                [ 3 ] Center for Ethics, Law and Mental Health (CELAM)University of Gothenburg GöteborgSweden
                [ 4 ] Gillberg Neuropsychiatry CentreUniversity of Gothenburg GöteborgSweden
                [ 5 ] Unit of Biostatistics IMMKarolinska Institutet StockholmSweden
                Author notes
                [*] [* ] Eva Norén Selinus, Department of Clinical Neuroscience, Centre for Psychiatry Research & Education, Karolinska Institutet & Stockholm County Council, CPF, Norra stationsgatan 69, plan 7, 11364 Stockholm, Sweden.

                E‐mail: eva.noren@ 123456ki.se

                Author information
                http://orcid.org/0000-0002-6104-7836
                Article
                ACPS12655
                10.1111/acps.12655
                5129548
                27714770
                73fd0553-995a-457e-b954-17043b7e62bf
                © 2016 The Authors. Acta Psychiatrica Scandinavica Published by John Wiley & Sons Ltd

                This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

                History
                : 19 September 2016
                Page count
                Figures: 1, Tables: 3, Pages: 13, Words: 9548
                Funding
                Funded by: Swedish Research Council
                Funded by: Hedlund Foundation
                Categories
                Original Article
                Original Articles
                Custom metadata
                2.0
                acps12655
                December 2016
                Converter:WILEY_ML3GV2_TO_NLMPMC version:4.9.8 mode:remove_FC converted:25.11.2016

                Clinical Psychology & Psychiatry
                attention deficit hyperactivity disorder,child and adolescent psychiatry,comorbidity,gender,behaviour

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