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      The antifungal strobilurins and their possible ecological role

      Canadian Journal of Botany

      Canadian Science Publishing

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          Antibiotic Substances From Basidiomycetes: VIII. Pleurotus Multilus (Fr.) Sacc. and Pleurotus Passeckerianus Pilat.

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            The strobilurins--new antifungal antibiotics from the basidiomycete Strobilurus tenacellus.

            The strobilurins are two antifungal antibiotics which were isolated from the mycelium of Strobilurus tenacellus strain No. 21602. The strobilurins A and B are highly active against yeasts and filamentous fungi. In vitro antitumor activity was tested using cells of the ascitic form of EHRLICH carcinoma. The strobilurins strongly inhibited the incorporation of radioactive leucine, uridine, and thymidine into the acid-insoluble fraction of cells (protein, RNA, and DNA). The molecular formulas as determined by high resolution mass spectrometry are C16H18O3 for strobilurin A and C17H19C1O4 for strobilurin B.
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              Antibiotics from basidiomycetes. IX. Oudemansin, an antifungal antibiotic from Oudemansiella mucida (Schrader ex Fr.) Hoehnel (Agaricales).

              From mycelial cultures of Oudemansiella mucida a crystalline optically active antibiotic, oudemansin (2), has been isolated; its structure is closely related to strobilurin A (1). The relative configuration of oudemansin have been determined by X-ray analysis. The antibiotic exhibits strong antifungal properties and inhibits respiration in fungi, cells of the ascitic form of EHRLICH carcinoma, and rat liver mitochondria.
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                Author and article information

                Journal
                Canadian Journal of Botany
                Can. J. Bot.
                Canadian Science Publishing
                0008-4026
                December 31 1995
                December 31 1995
                : 73
                : S1
                : 940-945
                Article
                10.1139/b95-342
                7408cea6-e69f-4769-8a4d-3ac0faa684fc
                © 1995
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