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      Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways.

      Journal of Lipid Research
      Animals, Antigens, CD36, metabolism, Biological Transport, Fatty Acids, Hormones, Humans, Lipolysis, Lipoprotein Lipase, Signal Transduction

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          Abstract

          Cells obtain FAs either from LPL-catalyzed hydrolysis of lipoprotein triglyceride or from unesterified FFAs associated with albumin. LPL also influences uptake of esterified lipids such as cholesteryl and retinyl esters that are not hydrolyzed in the plasma. This process might not involve LPL enzymatic activity. LPL is regulated by feeding/fasting, insulin, and exercise. Although a number of molecules may affect cellular uptake of FFAs, the best characterized is CD36. Genetic deletion of this multiligand receptor reduces FFA uptake into skeletal muscle, heart, and adipose tissue, and impairs intestinal chylomicron production and clearance of lipoproteins from the blood. CD36 is regulated by some of the same factors that regulate LPL, including insulin, muscle contraction, and fasting, in part, via ubiquitination. LPL and CD36 actions in various tissues coordinate biodistribution of fat-derived calories.

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          Author and article information

          Journal
          19033209
          2674753
          10.1194/jlr.R800085-JLR200

          Chemistry
          Animals,Antigens, CD36,metabolism,Biological Transport,Fatty Acids,Hormones,Humans,Lipolysis,Lipoprotein Lipase,Signal Transduction

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