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Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial
Daniel M Blumberger ,
Fidel Vila-Rodriguez ,
Kevin E Thorpe ,
Kfir Feffer ,
Yoshihiro Noda ,
Peter Giacobbe ,
Yuliya Knyahnytska ,
Sidney H Kennedy ,
Raymond W Lam ,
Zafiris J Daskalakis ,
Jonathan Downar
April 2018
April 2018
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
<p class="first" id="d5084202e219">Treatment-resistant major depressive disorder is
common; repetitive transcranial magnetic
stimulation (rTMS) by use of high-frequency (10 Hz) left-side dorsolateral prefrontal
cortex stimulation is an evidence-based treatment for this disorder. Intermittent
theta burst stimulation (iTBS) is a newer form of rTMS that can be delivered in 3
min, versus 37·5 min for a standard 10 Hz treatment session. We aimed to establish
the clinical effectiveness, safety, and tolerability of iTBS compared with standard
10 Hz rTMS in adults with treatment-resistant depression.
</p>