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      Animal models in epilepsy research: legacies and new directions.

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      Nature neuroscience

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          Abstract

          Human epilepsies encompass a wide variety of clinical, behavioral and electrical manifestations. Correspondingly, studies of this disease in nonhuman animals have brought forward an equally wide array of animal models; that is, species and acute or chronic seizure induction protocols. Epilepsy research has a long history of comparative anatomical and physiological studies on a range of mostly mammalian species. Nonetheless, a relatively limited number of rodent models have emerged as the primary choices for most investigations. In many cases, these animal models are selected on the basis of convenience or tradition, although technical or experimental rationale does, and should, factor into these decisions. More complex mammalian brains and genetic model organisms including zebrafish have been studied less, but offer substantial advantages that are becoming widely recognized.

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          Author and article information

          Journal
          Nat. Neurosci.
          Nature neuroscience
          1546-1726
          1097-6256
          Mar 2015
          : 18
          : 3
          Affiliations
          [1 ] Department of Neurological Surgery, University of California, San Francisco, California, USA.
          Article
          nn.3934
          10.1038/nn.3934
          25710835
          74296bff-b5b1-4f86-bbbd-6e316dd34f39
          History

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