BCR-ABL1 expression, RT-qPCR and treatment decisions in chronic myeloid leukaemia.

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Abstract

RT-qPCR is used to quantify minimal residual disease (MRD) in chronic myeloid leukaemia (CML) in order to make decisions on treatment, but its results depend on the level of BCR-ABL1 expression as well as leukaemic cell number. The aims of the study were to quantify inter-individual differences in expression level, to determine the relationship between expression level and response to treatment, and to investigate the effect of expression level on interpretation of the RT-qPCR result.

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Journal

Journal ID (iso-abbrev): J Clin Pathol

Title: Journal of clinical pathology

Publisher: BMJ

ISSN (Electronic): 1472-4146

ISSN (Print): 0021-9746

Publication date (Electronic): Sep 2016

Volume: 69

Issue: 9

Affiliations

[1 ] Department of Haematology & Genetic Pathology, School of Medicine, Flinders University and Medical Centre, Bedford Park, South Australia, Australia.

[2 ] Department of Haematology & Genetic Pathology, School of Medicine, Flinders University and Medical Centre, Bedford Park, South Australia, Australia Haematology Division, SA Pathology, Adelaide, South Australia, Australia.

[3 ] Centre for Cancer Biology, SA Pathology, Adelaide, South Australia, Australia.

[4 ] South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

[5 ] Haematology Division, SA Pathology, Adelaide, South Australia, Australia.

[6 ] Department of Haematology & Genetic Pathology, School of Medicine, Flinders University and Medical Centre, Bedford Park, South Australia, Australia Monoquant Pty Ltd, Adelaide, South Australia, Australia.

Article

Publisher Item ID: jclinpath-2015-203538

DOI: 10.1136/jclinpath-2015-203538

PubMed ID: 26837312

SO-VID: 7449d0ea-1d72-40ca-a5e4-521b46fcefa6

Copyright © Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

History

Keywords: CANCER GENETICS,CML,PCR

Data availability:

Keywords: CANCER GENETICS, CML, PCR

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