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      Synergistic Effects of Traumatic Head Injury and Apolipoprotein-epsilon4 in Patients With Alzheimer's Disease

      , , , , , , , ,

      Neurology

      Ovid Technologies (Wolters Kluwer Health)

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          Abstract

          The apolipoprotein-epsilon 4 allele increases the risk of Alzheimer's disease (AD), but cerebral deposition of beta-amyloid with age, a genetic mutation, or head injury may contribute to the pathogenesis of this disease. We examined the risks of AD associated with traumatic head injury and apolipoprotein-epsilon 4 in 236 community-dwelling elderly persons. A 10-fold increase in the risk of AD was associated with both apolipoprotein-epsilon 4 and a history of traumatic head injury, compared with a two-fold increase in risk with apolipoprotein-epsilon 4 alone. Head injury in the absence of an apolipoprotein-epsilon 4 allele did not increase risk. These data imply that the biological effects of head injury may increase the risk of AD, but only through a synergistic relationship with apolipoprotein-epsilon 4.

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          Author and article information

          Journal
          Neurology
          Neurology
          Ovid Technologies (Wolters Kluwer Health)
          0028-3878
          1526-632X
          March 01 1995
          March 01 1995
          : 45
          : 3
          : 555-557
          Article
          10.1212/WNL.45.3.555
          7898715
          744ecb2a-2c06-4caa-9a07-33e63276a567
          © 1995

          Molecular medicine, Neurosciences

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