Three new diterpenoid alkaloids isolated from  Aconitum brevicalcaratum

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Abstract

In the present study, three new aconitine-type diterpenoid alkaloids brochyponines A–C ( 1–3) were isolated from the roots of Aconitum brevicalcaratum. Their structures were established on the basis of extensive spectroscopic analyses (IR, HR-ESI-MS, and 1D and 2D NMR). The NMR data of salt form for compound 1 in CDCl ₃ were also measured.

Author and article information

Journal

Journal ID (publisher-id): CJNM

Title: Chinese Journal of Natural Medicines

Publisher: Elsevier

ISSN (Electronic): 1875-5364

Publication date (Electronic): 20 November 2018

Volume: 16

Issue: 11

Pages: 866-870

Affiliations

[1] ¹Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China

[2] ²Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zunyi Medical University Zhu-hai Campus, Zhuhai 519041, China

Author notes

*Corresponding authors: CAI Le, E-mail: caile@ 123456ynu.edu.cn ; DING Zhong-Tao, ztding@ 123456ynu.edu.cn

^ΔThese authors contributed equally to this work.

These authors have no conflict of interest to declare.

Article

Publisher ID: S1875-5364(18)30128-6

DOI: 10.1016/S1875-5364(18)30128-6

SO-VID: 74631eff-5245-4497-be6f-561125bff841

History

Date received : 18 May 2018

Funding

Funded by: National Natural Science Foundation of China

Award ID: 81460648

Funded by: Guizhou Science and Technology Foundation of China

Award ID: QKHJC[2018]1193

This project was financially supported by the National Natural Science Foundation of China (No. 81460648), Guizhou Science and Technology Foundation of China (No. QKHJC[2018]1193), Yunling Scholars of Yunnan province, and Program for Excellent Young Talents, Yunnan University.

ScienceOpen disciplines: Medicine,Pharmaceutical chemistry,Pharmacology & Pharmaceutical medicine,Complementary & Alternative medicine

Keywords: Aconitum brevicalcaratum ,Ranunculaceae,Diterpenoid alkaloid,Brochyponine

Data availability:

ScienceOpen disciplines: Medicine, Pharmaceutical chemistry, Pharmacology & Pharmaceutical medicine, Complementary & Alternative medicine

Keywords: Aconitum brevicalcaratum , Ranunculaceae, Diterpenoid alkaloid, Brochyponine