Steroid Metabolism  in vitro by Gonadal Tissue from a True Hermaphrodite

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Abstract

The case of a true hermaphrodite, with a normal ovary and an ovotestis is presented. The ovotestis was removed and incubated in vitro with tritiated steroids (testosterone, dehydroepiandrosterone, pregnenolone and 17α-hydroxyprogesterone). Labeled metabolites were isolated and identified. Based upon these findings, a pathway of steroid biogenesis in this abnormal gonadal tissue is suggested. The ovotestis studied did not contain all the enzymes involved in ovarian steroidogenesis: 3 β-hydroxysteroid dehydrogenase, isomerase, 17–20 desmolase and 17 β-hydroxysteroid dehydrogenase were present, but other important enzymes, such as 16 and 17-hydroxylases, and aromatizing enzyme systems, were deficient or absent. The biosynthesis of steroids has been studied in some abnormal conditions such as testicular feminization, Klinefelter’s syndrome, polycystic ovary and cancer. In the present study, the steroid metabolism in gonadal tissue from a true hermaphrodite was investigated in vitro.

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Author and article information

Journal

Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1979

Publication date (Print): 1979

Publication date (Electronic): 25 November 2008

Volume: 10

Issue: 6

Pages: 303-309

Affiliations

Human Reproduction Research Unit, Department of Obstetrics and Gynecology, Hôpital St.-Pierre, Brussels University, Brussels

Article

Publisher ID: 179012 Other ID: Horm Res 1979;10:303–309

DOI: 10.1159/000179012

PubMed ID: 157317

SO-VID: 74759dfc-0eee-40d1-8362-be4cd786db0b

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 07 May 1977

Date accepted : 31 July 1978

Page count

Pages: 7

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Steroid Metabolism in vitro by Gonadal Tissue from a True Hermaphrodite

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