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      Uveitis and Systemic Inflammatory Markers in Convalescent Phase of Ebola Virus Disease

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          Abstract

          We report a case of probable Zaire Ebola virus–related ophthalmologic complications in a physician from the United States who contracted Ebola virus disease in Liberia. Uveitis, immune activation, and nonspecific increase in antibody titers developed during convalescence. This case highlights immune phenomena that could complicate management of Ebola virus disease–related uveitis during convalescence.

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          Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients.

          Mpia A. Bwaka, Marie‐José Bonnet, Philippe Calain … (1999)
          During the 1995 outbreak of Ebola hemorrhagic fever in the Democratic Republic of the Congo, a series of 103 cases (one-third of the total number of cases) had clinical symptoms and signs accurately recorded by medical workers, mainly in the setting of the urban hospital in Kikwit. Clinical diagnosis was confirmed retrospectively in cases for which serum samples were available (n = 63, 61% of the cases). The disease began unspecifically with fever, asthenia, diarrhea, headaches, myalgia, arthralgia, vomiting, and abdominal pain. Early inconsistent signs and symptoms included conjunctival injection, sore throat, and rash. Overall, bleeding signs were observed in <45% of the cases. Typically, terminally ill patients presented with obtundation, anuria, shock, tachypnea, and normothermia. Late manifestations, most frequently arthralgia and ocular diseases, occurred in convalescent patients. This series is the most extensive number of cases of Ebola hemorrhagic fever observed during an outbreak.
          Article 0 comments Cited 124 times – based on 0 reviews     Review now
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            Persistence and genetic stability of Ebola virus during the outbreak in Kikwit, Democratic Republic of the Congo, 1995.

            L. L. Rodriguez, A. de Roo, Y Guimard … (1999)
            Ebola virus persistence was examined in body fluids from 12 convalescent patients by virus isolation and reverse transcription-polymerase chain reaction (RT-PCR) during the 1995 Ebola hemorrhagic fever outbreak in Kikwit, Democratic Republic of the Congo. Virus RNA could be detected for up to 33 days in vaginal, rectal, and conjunctival swabs of 1 patient and up to 101 days in the seminal fluid of 4 patients. Infectious virus was detected in 1 seminal fluid sample obtained 82 days after disease onset. Sequence analysis of an RT-PCR fragment of the most variable region of the glycoprotein gene amplified from 9 patients revealed no nucleotide changes. The patient samples were selected so that they would include some from a suspected line of transmission with at least three human-to-human passages, some from 5 survivors and 4 deceased patients, and 2 from patients who provided multiple samples through convalescence. There was no evidence of different virus variants cocirculating during the outbreak or of genetic variation accumulating during human-to-human passage or during prolonged persistence in individual patients.
            Article 0 comments Cited 107 times – based on 0 reviews     Review now
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              The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States.

              Colleen Kraft, Angela Hewlett, Scott Koepsell … (2015)
              The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management.
              Article 0 comments Cited 83 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Emerg Infect Dis
                Journal ID (iso-abbrev): Emerging Infect. Dis
                Journal ID (publisher-id): EID
                Title: Emerging Infectious Diseases
                Publisher: Centers for Disease Control and Prevention
                ISSN (Print): 1080-6040
                ISSN (Electronic): 1080-6059
                Publication date (Print): February 2016
                Volume: 22
                Issue: 2
                Pages: 295-297
                Affiliations
                [1]University of Massachusetts Medical School, Worcester, Massachusetts, USA (J.R. Chancellor, S.P. Padmanablan, T.C. Greenough, R. Sacra, R.T. Ellison III, L.C. Madoff, R.J. Droms, D.M. Hinkle, G.K. Asdourian, R.W. Finberg, O.M. Cerón);
                [2]Massachusetts Department of Public Health, Boston, Massachusetts, USA (L.C. Madoff);
                [3]Centers for Disease Control and Prevention, Atlanta, Georgia, USA (U. Stroher, T.M. Uyeki)
                Author notes
                Address for correspondence: Olga M. Cerón, Department of Ophthalmology, University of Massachusetts Medical School, UMass Memorial Eye Center, 281 Lincoln St, 3rd Floor, Worcester, MA 01605, USA; email: olga.ceron@ 123456umassmemorial.org
                Article
                Publisher ID: 15-1416
                DOI: 10.3201/eid2202.151416
                PMC ID: 4734519
                PubMed ID: 26812218
                SO-VID: 7482a588-9612-40a9-88fe-be008e2adf69
                History
                Categories
                Subject: Expedited
                Subject: Dispatch
                Subject: Dispatch
                Subject: Uveitis and Systemic Inflammatory Markers in Convalescent Phase of Ebola Virus Disease

                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: ebola hemorrhagic fever,ebola virus disease,ebola,ebola virus,viruses,uveitis,conjunctivitis,ocular manifestations,systemic inflammatory markers,immune privilege,convalescent phase,liberia
                Data availability:
                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: ebola hemorrhagic fever, ebola virus disease, ebola, ebola virus, viruses, uveitis, conjunctivitis, ocular manifestations, systemic inflammatory markers, immune privilege, convalescent phase, liberia

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