Blog
About

151
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking.

      Neurology

      cerebrospinal fluid, Biological Specimen Banks, standards, Consensus, Databases, Bibliographic, statistics & numerical data, Disability Evaluation, England, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Multiple Sclerosis, pathology, Severity of Illness Index, Specimen Handling, methods, Biological Markers

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in CSF are being used in clinical practice. One of the most critical factors in CSF biomarker research is the inadequate powering of studies because of the lack of sufficient samples that can be obtained in single-center studies. Therefore, collaboration between investigators is needed to establish large biobanks of well-defined samples. Standardized protocols for biobanking are a prerequisite to ensure that the statistical power gained by increasing the numbers of CSF samples is not compromised by preanalytical factors. Here, a consensus report on recommendations for CSF collection and biobanking is presented, formed by the BioMS-eu network for CSF biomarker research in multiple sclerosis. We focus on CSF collection procedures, preanalytical factors, and high-quality clinical and paraclinical information. The biobanking protocols are applicable for CSF biobanks for research targeting any neurologic disease.

          Related collections

          Author and article information

          Journal
          19949037
          2839806
          10.1212/WNL.0b013e3181c47cc2

          Comments

          Comment on this article