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Hints of hidden heritability in GWAS.

Publication date: 2010-06-30

Keywords: Body Height, genetics, Breast Neoplasms, Colorectal Neoplasms, Crohn Disease, Female, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, methods, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Prostatic Neoplasms

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Abstract

Although susceptibility loci identified through genome-wide association studies (GWAS) typically explain only a small proportion of the heritability, a classical quantitative genetic analysis now argues that considering together all common SNPs can explain a large proportion of the heritability of these complex traits. A related study provides recommendations for the sample sizes needed in future GWAS to identify additional susceptibility loci.

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PubMed ID:: 20581876

DOI:: 10.1038/ng0710-558

ScienceOpen disciplines: Chemistry

Keywords: Body Height,genetics,Breast Neoplasms,Colorectal Neoplasms,Crohn Disease,Female,Gene Frequency,Genetic Predisposition to Disease,Genome-Wide Association Study,methods,Genotype,Humans,Male,Polymorphism, Single Nucleotide,Prostatic Neoplasms

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ScienceOpen disciplines: Chemistry

Hints of hidden heritability in GWAS.

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