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      Hints of hidden heritability in GWAS.

      Nature genetics

      genetics, Prostatic Neoplasms, Polymorphism, Single Nucleotide, Male, Humans, Genotype, methods, Genome-Wide Association Study, Genetic Predisposition to Disease, Gene Frequency, Female, Crohn Disease, Colorectal Neoplasms, Breast Neoplasms, Body Height

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          Abstract

          Although susceptibility loci identified through genome-wide association studies (GWAS) typically explain only a small proportion of the heritability, a classical quantitative genetic analysis now argues that considering together all common SNPs can explain a large proportion of the heritability of these complex traits. A related study provides recommendations for the sample sizes needed in future GWAS to identify additional susceptibility loci.

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          Journal
          10.1038/ng0710-558
          20581876

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