Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis :  The RESTORE Randomized Clinical Trial

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Abstract

<p class="first" id="d10387997e273">Most clinical guidelines do not recommend platelet-rich plasma (PRP) for knee osteoarthritis (OA) because of lack of high-quality evidence on efficacy for symptoms and joint structure, but the guidelines emphasize the need for rigorous studies. Despite this, use of PRP in knee OA is increasing. </p>

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Title: JAMA

Abbreviated Title: JAMA

Publisher: American Medical Association (AMA)

ISSN (Print): 0098-7484

Publication date Created: November 23 2021

Publication date (Print): November 23 2021

Volume: 326

Issue: 20

Page: 2021

Affiliations

[1 ]Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia

[2 ]Rheumatology Department, Royal North Shore Hospital, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, New South Wales, Australia

[3 ]Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia

[4 ]Rheumatology Department, Alfred Hospital, Melbourne, Victoria, Australia

[5 ]Monash Department of Clinical Epidemiology, Cabrini Institute, Melbourne, Victoria, Australia

[6 ]Centre for Health Economics, Monash University, Melbourne, Victoria, Australia

[7 ]Imaging @ Olympic Park, Melbourne, Victoria, Australia

[8 ]Castlereagh Imaging, Sydney, New South Wales, Australia

[9 ]Monash Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia

[10 ]Biomarker Discovery Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

[11 ]Department of Physical Medicine and Rehabilitation, University of Medicine, Mandalay, Mandalay, Myanmar

Article

DOI: 10.1001/jama.2021.19415

PMC ID: 8611484

PubMed ID: 34812863

SO-VID: 749c68fd-9841-4485-9e96-fff66d7a02a4

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Self URI (article page): https://jamanetwork.com/journals/jama/fullarticle/2786501

Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis : The RESTORE Randomized Clinical Trial

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