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      Conservation demands safe gene drive

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      1 , * , 2 , *
      PLoS Biology
      Public Library of Science

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          Abstract

          Interest in developing gene drive systems to control invasive species is growing, with New Zealand reportedly considering the nascent technology as a way to locally eliminate the mammalian pests that threaten its unique flora and fauna. If gene drives successfully eradicated these invasive populations, many would rejoice, but what are the possible consequences? Here, we explore the risk of accidental spread posed by self-propagating gene drive technologies, highlight new gene drive designs that might achieve better outcomes, and explain why we need open and international discussions concerning a technology that could have global ramifications.

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          Most cited references19

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          BIOSAFETY. Safeguarding gene drive experiments in the laboratory.

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            The next generation of rodent eradications: Innovative technologies and tools to improve species specificity and increase their feasibility on islands

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              Biological invasions: What's worth fighting and what can be won?

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                Author and article information

                Journal
                PLoS Biol
                PLoS Biol
                plos
                plosbiol
                PLoS Biology
                Public Library of Science (San Francisco, CA USA )
                1544-9173
                1545-7885
                16 November 2017
                November 2017
                16 November 2017
                : 15
                : 11
                : e2003850
                Affiliations
                [1 ] MIT Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
                [2 ] Department of Anatomy, University of Otago, Dunedin, New Zealand
                Author notes

                The authors have declared that no competing interests exist.

                Author information
                http://orcid.org/0000-0003-0671-3637
                Article
                pbio.2003850
                10.1371/journal.pbio.2003850
                5689824
                29145398
                749d5849-63fe-4546-8daf-ed4b66433ae0
                © 2017 Esvelt, Gemmell

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                Page count
                Figures: 2, Tables: 0, Pages: 8
                Funding
                Burroughs Wellcome (grant number IRSA 1016432). Received by KME. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. DARPA Safe Genes (grant number N66001-17-2-4054). Received by KME. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NIH DP2 New Innovator (grant number AI136597-01). Received by KME. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Biological Heritage National Science Challenge. Received by NJG. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Perspective
                Ecology and Environmental Sciences
                Species Colonization
                Invasive Species
                Biology and Life Sciences
                Biotechnology
                Bioengineering
                Synthetic Bioengineering
                Genome Engineering
                Synthetic Genome Editing
                Crispr
                Engineering and Technology
                Bioengineering
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                Genome Engineering
                Synthetic Genome Editing
                Crispr
                Biology and Life Sciences
                Synthetic Biology
                Synthetic Bioengineering
                Genome Engineering
                Synthetic Genome Editing
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                Engineering and Technology
                Synthetic Biology
                Synthetic Bioengineering
                Genome Engineering
                Synthetic Genome Editing
                Crispr
                Biology and Life Sciences
                Synthetic Biology
                Synthetic Genomics
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                Engineering and Technology
                Synthetic Biology
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                People and places
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                Oceania
                New Zealand
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                Life sciences
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