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      Regulation of Somatomedin-C/Insulin-Like Growth Factor I by Nutrients

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          Abstract

          Nutritional intake is an important regulator of plasma somatomedin-C/insulin-like growth factor I (Sm-C/IGF-I) concentrations in plasma. Concentrations in humans are reduced to the hypopituitary range by fasting for only a few days, and their normalization after fasting depends on the adequacy of energy and protein in the refeeding diet. The changes correlate with changes in nitrogen balance. In rats we have observed a close relationship between change in plasma Sm-C/IGF-I and hepatic GH binding with fasting and refeeding, suggesting that alterations in GH binding might be responsible partly for changes in Sm-C/ IGF-I. When malnourished humans are given nutrient repletion, the increase in Sm-C/ IGF-I is far more dramatic than changes in other nutrient-related serum proteins.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-4453-5
          978-3-318-01944-5
          1663-2818
          1663-2826
          1986
          1986
          28 November 2008
          : 24
          : 2-3
          : 166-176
          Affiliations
          Department of Pediatrics and Medicine, The University of North Carolina at Chapel Hill, N.C., USA; Unité de Diabète et Nutrition, Catholic University of Louvain, Brussels, Belgium
          Article
          180556 Horm Res 1986;24:166–176
          10.1159/000180556
          3758932
          © 1986 S. Karger AG, Basel

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          Page count
          Pages: 11
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