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      Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome

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      Immunology and Allergy Clinics of North America

      Elsevier BV

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          Abstract

          The debate about whether asthma and chronic obstructive pulmonary disease (COPD) are distinct clinical syndromes is not new; there is heightened interest in understanding the group of individuals with obstructive lung disease who seem to have elements of both conditions because recent studies have demonstrated increased risk for respiratory events and exacerbations. We describe the clinical characteristics of this subtype of disease and suggest 4 working definitions of individuals who would fall into the asthma-COPD overlap category. Understanding the mechanisms underlying these subtypes will hopefully lead into a better understanding of therapeutic strategies that can target specific pathobiologic pathways.

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          Author and article information

          Journal
          Immunology and Allergy Clinics of North America
          Immunology and Allergy Clinics of North America
          Elsevier BV
          08898561
          August 2016
          August 2016
          : 36
          : 3
          : 515-528
          Article
          10.1016/j.iac.2016.03.003
          4943670
          27401623
          © 2016

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