The etiological agent of coronavirus disease 2019 (COVID-19), severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2), emerged in December 2019 in Wuhan, Hubei Province,
China [1]. SARS-CoV-2 has spread globally and the World Health Organization has declared
a global pandemic. As of May 2020, more than 5 million cases have been identified
worldwide, with more than 1.6 million cases in the United States alone. Numerous case
reports and features of SARS-CoV-2 infection in adults have been reported. Common
symptoms include, fever, myalgia, and dry cough [1]. Progression to pneumonia is most
often seen in patients with underlying conditions and the elderly [1]. In contrast,
there is a paucity of data on clinical presentation and course in pediatric SARS-CoV-2
infections, particularly among infants and neonates. The Chinese Center for Disease
Control and Prevention reported that children accounted for <1% of 72 314 COVID-19
cases and that pediatric disease was most often mild [1]. Additionally, the US Centers
for Disease Control and Prevention (CDC) reported that 1.7% of 150 000 COVID-19 cases
in the United States through 2 April 2020 occurred in patients aged <18 years, with
few requiring hospitalization [2].
Here, we report a case of COVID-19 in a 10-day-old infant with no underlying health
conditions who presented with acute respiratory failure. We discuss the clinical presentation,
treatment course, clinical outcomes, and testing of alternative sample types for the
presence of SARS-CoV-2.
CASE PRESENTATION
On 1 April 2020, a 10-day-old male born at 39 weeks’ gestation via normal spontaneous
vaginal delivery presented to the emergency department (ED) of a California hospital
with increased nasal secretion and labored breathing approximately 1 week after exposure
to his grandmother and older sibling who experienced upper respiratory symptoms the
week prior. No other family members reported being symptomatic. A capillary blood
gas (CBG) analysis revealed a pH of 7.36 and partial pressure of carbon dioxide (PCO2)
and oxygen (PO2) of 39 and 53 mm Hg, respectively; serum lactic acid was 4.1 mmol/L.
The patient was treated with oxygen by nasal cannula (NC). Oxygen saturation (SpO2)
on 2 L/min was 90%, and increased work of breathing (WOB) was noted; therefore, he
was escalated to 5 L/min high flow (HF) NC. Taken together, these findings were consistent
with hypoxic respiratory failure. Blood cultures were collected, and the patient was
placed empirically on intravenous ampicillin and gentamicin. He was immediately transferred
to the pediatric intensive care unit (PICU) at Children’s Hospital of Los Angeles
(CHLA) for higher-level care. A chest radiograph from the outside hospital demonstrated
bilateral ground-glass opacities with no focal consolidations suggestive of viral
etiology (Figure 1). On admission to the PICU, increased nasal flaring and secretions,
increased WOB, subcostal retractions, and lethargy were noted. He was afebrile with
no cough. The patient was continued on HFNC, and SpO2 was monitored hourly and kept
above 90%. His respiratory rate varied between 20 and 40 breaths/minute. Because he
demonstrated clinical improvement with SpO2 maintained at 99% on 5 L/min HFNC, he
was weaned to 0.5 L/min NC oxygen within 24 hours.
Figure 1.
Chest radiograph showing bilateral ground-glass opacities with no focal consolidations.
The image was obtained and provided by the outside hospital on the same day the patient
was admitted to Children’s Hospital of Los Angeles.
Overall, blood tests were unremarkable ,with slightly low mean corpuscular volume
and mean corpuscular hemoglobin (Supplementary Table 1). A nasopharyngeal (NP) swab
was collected, and SARS-CoV-2 RNA was detected by reverse transcriptase real-time
polymerase chain reaction (RT-PCR) using the CDC Emergency Use Authorization SARS-CoV-2
RT-PCR protocol and reported within 12 hours. Cycle threshold (Ct) values of 21.9
and 21.7 for neuraminidase gene targets 1 and 2 (N1, N2) were detected by the assay,
respectively. A FilmArray respiratory viral panel (FA-RVP) (BioFire Diagnostics, Salt
Lake City, UT) performed on the same specimen was negative, ruling out other viral
etiologies or viral coinfections (Supplementary Table 1). Additional SARS-CoV-2 RT-PCR
testing was performed on blood and a nares swab; SARS-CoV-2 was detected from nares
only. No antivirals were initiated. No other family members were tested for SARS-CoV-2
at that time.
The patient remained stable on 0.5 L/min NC oxygen and weaned to 0.25 L/min later
the same day. Normal appetite and fluid intake were noted, along with no apparent
respiratory distress. On day 3 of admission, the patient was successfully weaned off
NC oxygen to room air. Blood culture from the outside hospital grew Staphylococcus
epidermidis, which was deemed a contaminant. The patient was stable and afebrile on
day 4 of admission and was discharged.
The patient returned to CHLA ED 5 days later with increased nasal congestion, subcostal
retractions, and decreased feeding. He was afebrile with no other symptoms. SpO2 was
100% and CBG PCO2 and PO2 were slightly abnormal, measuring 46 and 43 mm Hg, respectively.
The mother, who was previously asymptomatic, was noted to have nasal congestion at
that time. NP swabs from the patient and the mother tested positive for SARS-CoV-2.
No other family members were tested. The patient’s NP swab exhibited Ct values of
31.1 and 34.8 for N1 and N2, respectively, qualitatively indicating a lower viral
load than the first NP specimen tested 5 days prior. At that time, the patient also
tested positive for human metapneumovirus by FA-RVP. On the same day, SARS-CoV-2 was
detected in stool, but a nares swab was negative. The patient was monitored overnight,
no investigational therapies were initiated, and his respiratory symptoms resolved.
He was stable on room air and discharged the next morning.
DISCUSSION
Here, we present a confirmed COVID-19 case in a 10-day-old full-term male with no
known underlying medical conditions who was hospitalized with acute respiratory failure
for approximately 3 days. The patient was managed with HFNC oxygen and did not require
invasive mechanical ventilation. Previous pediatric COVID-19 case reports indicate
that patients who required mechanical ventilation had preexisting conditions [3].
To date, few cases of COVID-19 in newborns have been published. A case report on a
confirmed SARS-CoV-2–positive pregnant woman and her newborn showed that the child
tested SARS-CoV-2–positive 36 hours after birth; the child was afebrile and stable
[4]. No treatment was needed despite the presence of a high-density nodular shadow
in the right lung [4]. Similarly, a 15-day-old infant admitted for fever, lethargy,
cutaneous mottling, respiratory distress, and cough was diagnosed with COVID-19; chest
X ray was normal, and supportive care was administered [5].
Several pediatric case series have been reported, with the majority from China. A
retrospective analysis of clinical data and chest computed tomography (CT) images
for 9 children diagnosed with COVID-19 showed that 5 were asymptomatic, 4 had fever,
2 had cough, and 1 had rhinorrhea. CT scans revealed ground-glass opacities with consolidation
(n = 6), nodular lesions (n = 6), or patchy lesions (n = 7) [6]. Another report of
10 children indicated no patients sought medical care directly but were tested for
SARS-CoV-2 due to exposure history and hospitalized only after testing positive [7].
Upon evaluation, most patients were febrile, but cough, sore throat, nasal congestion,
rhinorrhea, and diarrhea were less common, additionally 2 were asymptomatic [7]. Taken
together, infants and young children tend to range from being asymptomatic to having
mild/moderate clinical symptoms. However, as described in our case, these patients
can present with acute respiratory failure that requires noninvasive oxygen therapy.
Additionally, the epidemiological history of COVID-19–positive children is often linked
to family cluster and exposure to sick contacts [3,6]. This was also the case for
our patient who lives with 7 relatives and presented following exposure to ill family
members at home.
Detection of SARS-CoV-2 from alternate sources, including stool/rectal swabs, alternative
respiratory samples other than NP swabs, urine, and blood, have been documented in
a small subset of studies. Here, we report 2 separate NP swabs from the same patient
collected approximately 8 days apart, both of which tested positive for SARS-CoV-2
via RT-PCR. Despite an initial positive nares swab, subsequent sampling upon readmission
was negative, indicating lower clinical sensitivity compared with the NP swab. However,
SARS-CoV-2 was detected from fresh stool collected approximately 8 days after initial
presentation. Interestingly, fecal viral shedding up to 27 days after admission was
reported in children, while paired NP specimens from the same patients tested negative
[7]. Intermittent shedding and prolonged SARS-CoV-2 shedding were reported in a child
with 2 consecutive negative tests for both NP and rectal swabs, but the child was
positive by rectal swab 6 days later [7]. Current data suggest respiratory samples
and stool/rectal swabs are appropriate specimen types for SARS-CoV-2 testing in pediatric
patients, with stool/rectal swabs having higher potential utility for monitoring viral
shedding. Overall, this case represents a unique presentation of respiratory failure
due to SARS-CoV-2 in a neonatal patient and expands the clinical spectrum of pediatric
COVID-19.
CONCLUSIONS
More extensive studies are needed to better understand the pediatric disease spectrum
and clinical outcomes of COVID-19, particularly in newborns and children aged <1 year.
It is important for pediatricians to know that COVID-19 could potentially present
as respiratory failure in young children, given that current clinical data indicate
that children most often do not require oxygen therapy, intensive care support, and/or
invasive mechanical ventilation. Pleural effusion, enlarged lymph nodes, or progression
to pneumonia that occurs in critically ill adults was not seen in our patient, nor
are these common in children based on other reports. Last, while respiratory and,
potentially, stool specimens have high yield of SARS-CoV-2 detection in children,
the prevalence of viremia appears to be low.
Supplementary Material
piaa064_suppl_Supplementary_Material
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