The common functional polymorphism -50G>T of the CYP2J2 gene is not associated with ischemic coronary and cerebrovascular events in an urban-based sample of Swedes.

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Abstract

CYP2J2 is responsible for the production of 5,6 8,9 11,12 and 14,15-epoxyeicosatrienoic acids, vasodilator and anti-inflammatory substances. It is abundantly expressed in human heart and also present in kidney and vasculature. Carriers of a common polymorphism, the CYP2J2 -50G>T, rs890293, have reduced expression of CYP2J2 mRNA level in the heart putatively through the interference with a binding site for a transcription factor with consequently reduced circulating levels of CYP2J2 epoxygenase metabolites in vivo.

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Journal

Journal ID (iso-abbrev): J. Hypertens.

Title: Journal of hypertension

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1473-5598

ISSN (Print): 0263-6352

Publication date (Electronic): Feb 2010

Volume: 28

Issue: 2

Affiliations

[1 ] Department of Clinical Sciences, Lund University, University Hospital of Malmö, Sweden. cristiano.fava@med.lu.se

Article

DOI: 10.1097/HJH.0b013e328333097e

PubMed ID: 19851119

SO-VID: 74f108f1-4513-4862-851e-c61240457697

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