The Gene Polymorphism of IL-17 G-152A is Associated with Increased Colonization of Streptococcus pneumoniae in Young Finnish Children.

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Abstract

Streptococcus pneumoniae is a common respiratory pathogen, and up to 50% of children acquire S. pneumoniae in their nasopharynx during the first 12 months of life. The cytokine interleukin-17A (IL-17A) plays an important role in host defense against extracellular bacterial pathogens. We investigated the effect of IL-17 G-152A polymorphism on pneumococcal colonization in children.

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Journal

Journal ID (iso-abbrev): Pediatr. Infect. Dis. J.

Title: The Pediatric infectious disease journal

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1532-0987

ISSN (Print): 0891-3668

Publication date (Electronic): Sep 2015

Volume: 34

Issue: 9

Affiliations

[1 ] From the *Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Turku, Finland; †Department of Pediatrics, Turku University Hospital, Turku, Finland; ‡Turku Institute for Child and Youth Research, §The immunogenetics Laboratory, University of Turku, Finland; ¶Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland; and ‖Department of Medical Microbiology and Immunology, University of Turku, Finland.

Article

Publisher Item ID: 00006454-201509000-00003

DOI: 10.1097/INF.0000000000000691

PubMed ID: 26376306

SO-VID: 750f4cad-b282-4c31-b720-ce66dcbc303a

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