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      Pleiotropic effects of angiotensin receptor blockers: addressing comorbidities by optimizing hypertension therapy.

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      Journal of clinical hypertension (Greenwich, Conn.)
      Wiley

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          Abstract

          The efficacy of angiotensin receptor blockers (ARBs) in the management of hypertension is well established. Whether these agents induce pleiotropic effects that promote the amelioration of vascular disorders independent of blood pressure reduction remains controversial. This review examines preclinical and clinical data that highlight a potentially important role for ARBs in several common vascular disorders, including cardiovascular, cerebrovascular, renal, and metabolic disorders. The preponderance of evidence suggests that some of the benefits derived from ARBs might improve outcomes in these disorders by actions that extend beyond blood pressure reduction. This review also identifies some potentially important differences in the mechanism of action between ARBs and angiotensin-converting enzyme inhibitors that may have clinical significance in the management of vascular diseases.

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          Author and article information

          Journal
          J Clin Hypertens (Greenwich)
          Journal of clinical hypertension (Greenwich, Conn.)
          Wiley
          1751-7176
          1524-6175
          Jan 2011
          : 13
          : 1
          Affiliations
          [1 ] Department of Preventive Cardiology, Sterling Rock Falls Clinic, Sterling, IL 61081, USA. peter.toth@srfc.com
          Article
          10.1111/j.1751-7176.2010.00379.x
          21214721
          7515667b-bf94-4f1b-9aa8-aee4811361ff
          History

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