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      Floppy eyelid syndrome and ectropion improvement after 1 month of 0.03% Bimatoprost topical therapy

      case-report

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          Abstract

          Purpose

          To report the clinical improvement observed in a glaucomatous patient affected by floppy eyelid syndrome and ectropion after treatment with Bimatoprost 0.03%.

          Methods

          Retrospective observational case report of a single glaucomatous patient (caucasian, 82 years old) affected by floppy eyelid syndrome with marked eyelid laxity and ectropion after 1 month of once a day 0.03% Bimatoprost ocular drop administration.

          Results

          We observed a reduction of intraocular pressure (36% in the right eye and 37.5% in the left eye) and an unexpected improvement of eyelid laxity and inferior ectropion after 1 month of therapy with topical 0.03% Bimatoprost. Secondary outcomes were the improvement of the related ocular surface diseases and the decrease of the upper eyelid dermatochalasis. No side effect in terms of conjunctival inflammation and eyelashes growth was observed.

          Conclusions and Importance

          The first observational clinical case of a possible prostaglandin therapeutic effect on periocular tissue improving the laxity and malposition of the eyelids in a patient with floppy eyelid syndrome associated with inferior eyelid ectropion.

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          Most cited references11

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          Ocular findings in sleep apnoea patients using continuous positive airway pressure.

          To describe ocular findings in patients with established obstructive sleep apnoea hypopnoea syndrome (OSAHS) using continuous positive airway pressure (CPAP).
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            The floppy eyelid syndrome.

            We examined 11 overweight men, ranging in age from 34 to 56 years, who had the floppy eyelid syndrome, a disorder of unknown origin manifested by an easily everted, floppy upper eyelid and papillary conjunctivitis of the upper palpebral conjunctiva. The upper eyelid everts during sleep, resulting in irritation, papillary conjunctivitis, and conjunctival keratinization. Effective treatment consists of preventing the upper eyelid from everting while the patient is sleeping.
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              The Pathogenesis of floppy eyelid syndrome: involvement of matrix metalloproteinases in elastic fiber degradation.

              To investigate histopathologic alterations of eyelid biopsy specimens from patients with floppy eyelid syndrome (FES) with special regard to elastic fiber content and ultrastructure as well as to the expression of elastin-degrading enzymes to elucidate the pathogenesis of this disorder.
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                Author and article information

                Contributors
                Journal
                Am J Ophthalmol Case Rep
                Am J Ophthalmol Case Rep
                American Journal of Ophthalmology Case Reports
                Elsevier
                2451-9936
                23 September 2020
                December 2020
                23 September 2020
                : 20
                : 100938
                Affiliations
                [a ]Ophthalmic Unit, San Bassiano Hospital, Bassano Del Grappa, Italy
                [b ]Eye Clinic, Department of Neuroscience, Biomedicine and Movement, University of Verona, Italy
                [c ]Department of Sense Organs, Faculty of Medicine and Odontology, Umberto I Policlinic, Sapienza University of Rome, Italy
                Author notes
                []Corresponding author. San Bassiano Hospital, Via dei Lotti 40, Bassano del Grappa, 36061, Vicenza, Italy. adegre3@ 123456gmail.com
                Article
                S2451-9936(20)30253-X 100938
                10.1016/j.ajoc.2020.100938
                7581822
                75161a7e-3c87-4a9f-98b4-1b4d2d5d1bfe
                © 2020 The Authors

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 17 June 2019
                : 22 April 2020
                : 20 September 2020
                Categories
                Case Report

                floppy eyelid syndrome,prostaglandins,bimatoprost,eyelid laxity,ectropion,prostaglandin associated periorbitopathy

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